Testing of fibrous membranes with different scaffold morphology for development of 3D skin model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412732" target="_blank" >RIV/00216208:11130/20:10412732 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.4028/www.scientific.net/KEM.834.148" target="_blank" >https://doi.org/10.4028/www.scientific.net/KEM.834.148</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.148" target="_blank" >10.4028/www.scientific.net/KEM.834.148</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Testing of fibrous membranes with different scaffold morphology for development of 3D skin model

Popis výsledku v původním jazyce

Replacement of in vivo testing using advanced 3D constructs is an important challenge in tissue engineering applications. The cell culture material should be biocompatible and should mimic the natural microenvironment of the existing tissue. Nanofibrous scaffolds prepared by electrospinning from biocompatible polymers have suitable properties for cell culture in a 3D environment. Thanks to the high volume-to-surface ratio, controlled porous structure with high pore interconnection and microarchitecture in the nanoscale range, nanofibers are in the foreground of interest. We tested membranes with different topography with keratinocyte and fibroblast cell lines. Fibroblast showed stable growth with no difference among the scaffolds. On the other hand, keratinocytes preferred scaffolds with nanofiber morphology.

Název v anglickém jazyce

Testing of fibrous membranes with different scaffold morphology for development of 3D skin model

Popis výsledku anglicky

Replacement of in vivo testing using advanced 3D constructs is an important challenge in tissue engineering applications. The cell culture material should be biocompatible and should mimic the natural microenvironment of the existing tissue. Nanofibrous scaffolds prepared by electrospinning from biocompatible polymers have suitable properties for cell culture in a 3D environment. Thanks to the high volume-to-surface ratio, controlled porous structure with high pore interconnection and microarchitecture in the nanoscale range, nanofibers are in the foreground of interest. We tested membranes with different topography with keratinocyte and fibroblast cell lines. Fibroblast showed stable growth with no difference among the scaffolds. On the other hand, keratinocytes preferred scaffolds with nanofiber morphology.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Key Engineering Materials

ISBN

978-3-0357-1519-4

Počet stran výsledku

7

Strana od-do

148-154

Počet stran knihy

182

Název nakladatele

Trans Tech Publications Ltd

Místo vydání

Švýcarsko

Kód UT WoS kapitoly

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