Růstové databáze a registry - cesta k poznání fyziologických účinků růstového hormonu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10415812" target="_blank" >RIV/00216208:11130/20:10415812 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/20:10415812

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=e2qfsTeMwe" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=e2qfsTeMwe</a>

DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

Růstové databáze a registry - cesta k poznání fyziologických účinků růstového hormonu

Popis výsledku v původním jazyce

Growth hormone (GH) has been used as a drug since 1956. Since mid-1980s, recombinant human growth hormone has been available for the treatment. The recombinant production of GH has contributed to extending the indication of treatment and significantly increasing the number of treated patients. In the past 35 years, growth databases and registers have been used to monitor the physiological effects of growth hormone treatment in routine practice by collecting clinical data about treated patients. The first and most extensive KIGS database contains data about more than 83,000 children. Based on this database, robust mathematical models have been developed, which are predicting the effects of growth hormone treatment. The GeNeSIS database contains more than 22,000 children. Simultaneously it contributed to understanding the genetic etiology of growth hormone deficiency and to assessing the potential risks of therapy. Nordinet(R) IOS has data on nearly 18,000 children. The last, smallest, but unique is the ECOS database, which, thanks to the web-based data collection about each injection, provide to assess the adherence and compliance of patients and their impact on the effect of therapy. Growth databases and registers helped to understand the algorithms of growth hormone treatment, also contributed to its optimization and particularly to more effective use of financial means for the treatment.

Název v anglickém jazyce

Growth databases and registries - towards understanding physiological effects of growth hormone

Popis výsledku anglicky

Growth hormone (GH) has been used as a drug since 1956. Since mid-1980s, recombinant human growth hormone has been available for the treatment. The recombinant production of GH has contributed to extending the indication of treatment and significantly increasing the number of treated patients. In the past 35 years, growth databases and registers have been used to monitor the physiological effects of growth hormone treatment in routine practice by collecting clinical data about treated patients. The first and most extensive KIGS database contains data about more than 83,000 children. Based on this database, robust mathematical models have been developed, which are predicting the effects of growth hormone treatment. The GeNeSIS database contains more than 22,000 children. Simultaneously it contributed to understanding the genetic etiology of growth hormone deficiency and to assessing the potential risks of therapy. Nordinet(R) IOS has data on nearly 18,000 children. The last, smallest, but unique is the ECOS database, which, thanks to the web-based data collection about each injection, provide to assess the adherence and compliance of patients and their impact on the effect of therapy. Growth databases and registers helped to understand the algorithms of growth hormone treatment, also contributed to its optimization and particularly to more effective use of financial means for the treatment.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30209 - Paediatrics

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česko-slovenská pediatrie

ISSN

0069-2328

e-ISSN

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Svazek periodika

75

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

251-255

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85090641489