Tissue engineering and regenerative medicine in spinal cord injury repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10441268" target="_blank" >RIV/00216208:11130/20:10441268 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/B978-0-12-818084-6.00008-8" target="_blank" >https://doi.org/10.1016/B978-0-12-818084-6.00008-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-818084-6.00008-8" target="_blank" >10.1016/B978-0-12-818084-6.00008-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tissue engineering and regenerative medicine in spinal cord injury repair

Popis výsledku v původním jazyce

Spinal cord injury (SCI) is a devastating trauma that often leads to a permanent loss of motor and sensory functions, pain, and spasticity. A functional repair of injured tissue in the adult central nervous system remains a major issue for current biomedical research and its advancing clinical translation. Regenerative medicine, together with tissue engineering and various interdisciplinary methods, may offer new approaches to reduce neuronal death, glial scars at the injury site, and induce axonal regeneration. In this review we introduce SCI, its pathophysiology, available experimental models, and behavioral testing, which have been used for its further study. We also provide a comprehensive overview of selected experimental approaches based on cell transplantation, antioxidative treatment, laser therapy, biomaterial scaffolds, and their combinations. Finally, we consider the future direction of spinal neuromodulation research such as electrical stimulation or molecular manipulation, which could overcome molecular barriers inhibiting axonal growth to promote regeneration.

Název v anglickém jazyce

Tissue engineering and regenerative medicine in spinal cord injury repair

Popis výsledku anglicky

Spinal cord injury (SCI) is a devastating trauma that often leads to a permanent loss of motor and sensory functions, pain, and spasticity. A functional repair of injured tissue in the adult central nervous system remains a major issue for current biomedical research and its advancing clinical translation. Regenerative medicine, together with tissue engineering and various interdisciplinary methods, may offer new approaches to reduce neuronal death, glial scars at the injury site, and induce axonal regeneration. In this review we introduce SCI, its pathophysiology, available experimental models, and behavioral testing, which have been used for its further study. We also provide a comprehensive overview of selected experimental approaches based on cell transplantation, antioxidative treatment, laser therapy, biomaterial scaffolds, and their combinations. Finally, we consider the future direction of spinal neuromodulation research such as electrical stimulation or molecular manipulation, which could overcome molecular barriers inhibiting axonal growth to promote regeneration.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of Innovations in Central Nervous System Regenerative Medicine

ISBN

978-0-12-818084-6

Počet stran výsledku

42

Strana od-do

291-332

Počet stran knihy

686

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Kód UT WoS kapitoly

—