Sleep Disorders and Cognitive Aging among Cognitively Impaired vs. Unimpaired Older Adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F24%3A10471069" target="_blank" >RIV/00216208:11130/24:10471069 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1NmnhtlCP1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1NmnhtlCP1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/geront/gnad152" target="_blank" >10.1093/geront/gnad152</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sleep Disorders and Cognitive Aging among Cognitively Impaired vs. Unimpaired Older Adults

Popis výsledku v původním jazyce

BACKGROUND AND OBJECTIVES: Sleep disorders often predict or co-occur with cognitive decline. Yet, little is known how the relationship unfolds among older adults at risk for cognitive decline.To examine the associations of sleep disorders with cognitive decline in older adults with unimpaired cognition, or impaired cognition (mild cognitive impairment [MCI] and dementia). RESEARCH DESIGN AND METHODS: 5,822 participants (Mage=70) of the National Alzheimer&apos;s Coordinating Center database with unimpaired or impaired cognition were followed for three subsequent waves. Four types of clinician-diagnosed sleep disorders were reported: sleep apnea, hyposomnia/insomnia, REM sleep behavior disorder, or &quot;other.&quot; Cognition over time was measured by the Montreal Cognitive Assessment (MoCA) or an estimate of general cognitive ability (GCA) derived from scores based on 12 neuropsychological tests. Growth curve models were estimated adjusting for covariates. RESULTS: In participants with impaired cognition, baseline sleep apnea was related to better baseline MoCA performance (b=0.65, 95%CI=[0.07, 1.23]) and less decline in GCA over time (b=0.06, 95%CI=[0.001, 0.12]). Baseline insomnia was related to better baseline MoCA (b=1.54, 95%CI=[0.88, 2.21]) and less decline in MoCA over time (b=0.56, 95%CI=[0.20, 0.92]). Furthermore, having more sleep disorders (across the four types) at baseline predicted better baseline MoCA and GCA, and less decline in MoCA and GCA over time. These results were only found in those with impaired cognition and generally consistent when using self-reported symptoms of sleep apnea or insomnia. DISCUSSION AND IMPLICATIONS: Participants with sleep disorder diagnoses may have better access to healthcare, which may help maintain cognition through improved sleep.

Název v anglickém jazyce

Sleep Disorders and Cognitive Aging among Cognitively Impaired vs. Unimpaired Older Adults

Popis výsledku anglicky

BACKGROUND AND OBJECTIVES: Sleep disorders often predict or co-occur with cognitive decline. Yet, little is known how the relationship unfolds among older adults at risk for cognitive decline.To examine the associations of sleep disorders with cognitive decline in older adults with unimpaired cognition, or impaired cognition (mild cognitive impairment [MCI] and dementia). RESEARCH DESIGN AND METHODS: 5,822 participants (Mage=70) of the National Alzheimer&apos;s Coordinating Center database with unimpaired or impaired cognition were followed for three subsequent waves. Four types of clinician-diagnosed sleep disorders were reported: sleep apnea, hyposomnia/insomnia, REM sleep behavior disorder, or &quot;other.&quot; Cognition over time was measured by the Montreal Cognitive Assessment (MoCA) or an estimate of general cognitive ability (GCA) derived from scores based on 12 neuropsychological tests. Growth curve models were estimated adjusting for covariates. RESULTS: In participants with impaired cognition, baseline sleep apnea was related to better baseline MoCA performance (b=0.65, 95%CI=[0.07, 1.23]) and less decline in GCA over time (b=0.06, 95%CI=[0.001, 0.12]). Baseline insomnia was related to better baseline MoCA (b=1.54, 95%CI=[0.88, 2.21]) and less decline in MoCA over time (b=0.56, 95%CI=[0.20, 0.92]). Furthermore, having more sleep disorders (across the four types) at baseline predicted better baseline MoCA and GCA, and less decline in MoCA and GCA over time. These results were only found in those with impaired cognition and generally consistent when using self-reported symptoms of sleep apnea or insomnia. DISCUSSION AND IMPLICATIONS: Participants with sleep disorder diagnoses may have better access to healthcare, which may help maintain cognition through improved sleep.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30227 - Geriatrics and gerontology

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Gerontologist

ISSN

0016-9013

e-ISSN

1758-5341

Svazek periodika

64

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

gnad152

Kód UT WoS článku

001107672300001

EID výsledku v databázi Scopus

2-s2.0-85190832659