Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F24%3A10477331" target="_blank" >RIV/00216208:11130/24:10477331 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/24:10477331

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=f9lkZ-sNFU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=f9lkZ-sNFU</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2023.284128" target="_blank" >10.3324/haematol.2023.284128</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia

Popis výsledku v původním jazyce

We show that there is a marked difference in the percentage of BTRI/all SNVsbetween young children and older children, adolescents, and adults in HeH ALL. We interpret this asmost HeH ALL occurring in patients &lt;10 years at diagnosis, constituting the majority of cases, have aprenatal origin of the chromosomal gains, in line with previous findings.4-13 In contrast, HeH ALLoccurring in older children, adolescents, and adults generally have a later, most likely postnatal,origin of the chromosomal gains. Notably, some cases in young children may also fall into this group,suggesting a hitherto unknown heterogeneity within HeH ALL. Considering that we have recentlyshown that the chromosomal gains occur simultaneously and very early in the leukemogenesis ofHeH ALL,15 we deem it likely that this means that also the ALL arises postnatally in these cases,although we cannot definitely exclude another, as yet hidden, primary event.

Název v anglickém jazyce

Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia

Popis výsledku anglicky

We show that there is a marked difference in the percentage of BTRI/all SNVsbetween young children and older children, adolescents, and adults in HeH ALL. We interpret this asmost HeH ALL occurring in patients &lt;10 years at diagnosis, constituting the majority of cases, have aprenatal origin of the chromosomal gains, in line with previous findings.4-13 In contrast, HeH ALLoccurring in older children, adolescents, and adults generally have a later, most likely postnatal,origin of the chromosomal gains. Notably, some cases in young children may also fall into this group,suggesting a hitherto unknown heterogeneity within HeH ALL. Considering that we have recentlyshown that the chromosomal gains occur simultaneously and very early in the leukemogenesis ofHeH ALL,15 we deem it likely that this means that also the ALL arises postnatally in these cases,although we cannot definitely exclude another, as yet hidden, primary event.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Haematologica

ISSN

0390-6078

e-ISSN

1592-8721

Svazek periodika

109

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

5

Strana od-do

1951-1955

Kód UT WoS článku

001250402000039

EID výsledku v databázi Scopus

2-s2.0-85195227110