Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10488848" target="_blank" >RIV/00216208:11130/25:10488848 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Hl6m15fFJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Hl6m15fFJ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/geronb/gbae199" target="_blank" >10.1093/geronb/gbae199</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults

Popis výsledku v původním jazyce

OBJECTIVES: This study examined the association between childhood adversity and late-life cognitive outcomes among older Puerto Rican adults. METHODS: Data were from the PREHCO study, a population-based cohort of 3,713 older Puerto Rican adults (mean age 72.5 years; 60% female). Adverse childhood experiences (ACEs) were categorised into four factors: economic hardship, parental illiteracy, childhood illness, and neighbourhood disadvantage. Cognition was assessed with the Mini-Mental Cabán (MMC). For our analyses, cognitive impairment was defined as scoring 1.5 SD below expected score, adjusted for age, sex, education, and reading ability. Ordinal logistic regression (baseline) and generalised linear mixed models (all three waves) analysed MMC scores; generalised estimating equations assessed incident cognitive impairment (waves 2 and 3). RESULTS: All four adversity factors were associated with poorer MMC scores at baseline. Parental illiteracy (β=-0.35, p&lt;.001) and neighbourhood disadvantage (β=-0.27, p&lt;.001) showed stronger associations than economic hardship (β=-0.10, p=.003) and childhood illness (β=-0.21, p&lt;.001). No factors were significantly related to changes in cognitive scores over time. Depressive symptoms and self-rated health partially mediated cross-sectional relationships, with depressive symptoms showing a stronger effect. All adversity factors except economic hardship were linked to baseline cognitive impairment (OR=1.42 parent illiteracy, OR=1.24 childhood illness, OR=1.82 neighbourhood disadvantage, p&lt;.05). Only neighbourhood disadvantage was associated with incident cognitive impairment (OR=1.19, p=.003). DISCUSSION: This study highlights the lasting impact of childhood adversity on late-life cognitive health among older Puerto Ricans, suggesting that addressing early adversity may promote cognitive health later in life.

Název v anglickém jazyce

Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults

Popis výsledku anglicky

OBJECTIVES: This study examined the association between childhood adversity and late-life cognitive outcomes among older Puerto Rican adults. METHODS: Data were from the PREHCO study, a population-based cohort of 3,713 older Puerto Rican adults (mean age 72.5 years; 60% female). Adverse childhood experiences (ACEs) were categorised into four factors: economic hardship, parental illiteracy, childhood illness, and neighbourhood disadvantage. Cognition was assessed with the Mini-Mental Cabán (MMC). For our analyses, cognitive impairment was defined as scoring 1.5 SD below expected score, adjusted for age, sex, education, and reading ability. Ordinal logistic regression (baseline) and generalised linear mixed models (all three waves) analysed MMC scores; generalised estimating equations assessed incident cognitive impairment (waves 2 and 3). RESULTS: All four adversity factors were associated with poorer MMC scores at baseline. Parental illiteracy (β=-0.35, p&lt;.001) and neighbourhood disadvantage (β=-0.27, p&lt;.001) showed stronger associations than economic hardship (β=-0.10, p=.003) and childhood illness (β=-0.21, p&lt;.001). No factors were significantly related to changes in cognitive scores over time. Depressive symptoms and self-rated health partially mediated cross-sectional relationships, with depressive symptoms showing a stronger effect. All adversity factors except economic hardship were linked to baseline cognitive impairment (OR=1.42 parent illiteracy, OR=1.24 childhood illness, OR=1.82 neighbourhood disadvantage, p&lt;.05). Only neighbourhood disadvantage was associated with incident cognitive impairment (OR=1.19, p=.003). DISCUSSION: This study highlights the lasting impact of childhood adversity on late-life cognitive health among older Puerto Ricans, suggesting that addressing early adversity may promote cognitive health later in life.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journals of Gerontology - Series B Psychological Sciences and Social Sciences

ISSN

1079-5014

e-ISSN

1758-5368

Svazek periodika

80

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

gbae199

Kód UT WoS článku

001482377700001

EID výsledku v databázi Scopus

2-s2.0-105002429909