Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10499813" target="_blank" >RIV/00216208:11130/25:10499813 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hfJpNEJzsf" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hfJpNEJzsf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envres.2025.122380" target="_blank" >10.1016/j.envres.2025.122380</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood

Popis výsledku v původním jazyce

This study evaluates effects of a mixture of 29 chemicals in pregnancy (organochlorine compounds, per - and polyfluoroalkyl substances, phenols, and phthalates) on cognitive abilities (working memory, attentional function, visuomotor attention, cognitive flexibility, verbal and non-verbal intelligence, information processing speed, risky decision making) and fine motor function in childhood. Data from over 2000 mothers and their children that take part in the INfancia y Medio Ambiente in Spain were analyzed. Quantile-based g-computation estimated joint effects of chemical mixtures on the outcomes, adjusting for confounders and using inverse probability weights to mitigate selection bias. The overall mixture of chemicals was linked to lower visuomotor attention (+ 0.2 min., 95 % CI 0.0 to 0.4 for the second; + 0.4 min., 95 % CI 0.0 to 0.8 for the third; and + 0.7 min., 95 % CI 0.0 to 1.3 for the fourth quartile, relative to the first quartile). Counterintuitively, the overall mixture of chemicals was related to higher verbal intelligence (+ 1.5 points, 95 % CI 0.1 to 3.0 for the second; + 3.0 points, 95 % CI 0.1 to 6.0 for the third; and + 4.6 points, 95 % CI 0.2 to 9.0 for the fourth quartile, relative to the first quartile). However, neither of these associations survived multiple testing correction. Our study does not provide strong evidence that prenatal exposure to a mixture of organochlorine compounds, per - and polyfluoroalkyl substances, phenols, and phthalates affects cognitive abilities or fine motor function in childhood.

Název v anglickém jazyce

Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood

Popis výsledku anglicky

This study evaluates effects of a mixture of 29 chemicals in pregnancy (organochlorine compounds, per - and polyfluoroalkyl substances, phenols, and phthalates) on cognitive abilities (working memory, attentional function, visuomotor attention, cognitive flexibility, verbal and non-verbal intelligence, information processing speed, risky decision making) and fine motor function in childhood. Data from over 2000 mothers and their children that take part in the INfancia y Medio Ambiente in Spain were analyzed. Quantile-based g-computation estimated joint effects of chemical mixtures on the outcomes, adjusting for confounders and using inverse probability weights to mitigate selection bias. The overall mixture of chemicals was linked to lower visuomotor attention (+ 0.2 min., 95 % CI 0.0 to 0.4 for the second; + 0.4 min., 95 % CI 0.0 to 0.8 for the third; and + 0.7 min., 95 % CI 0.0 to 1.3 for the fourth quartile, relative to the first quartile). Counterintuitively, the overall mixture of chemicals was related to higher verbal intelligence (+ 1.5 points, 95 % CI 0.1 to 3.0 for the second; + 3.0 points, 95 % CI 0.1 to 6.0 for the third; and + 4.6 points, 95 % CI 0.2 to 9.0 for the fourth quartile, relative to the first quartile). However, neither of these associations survived multiple testing correction. Our study does not provide strong evidence that prenatal exposure to a mixture of organochlorine compounds, per - and polyfluoroalkyl substances, phenols, and phthalates affects cognitive abilities or fine motor function in childhood.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Research

ISSN

0013-9351

e-ISSN

1096-0953

Svazek periodika

285

Číslo periodika v rámci svazku

Part 2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

122380

Kód UT WoS článku

001545453100012

EID výsledku v databázi Scopus

2-s2.0-105011859521