Long-term prognosis and treatment outcomes in infantile and neonatal brain tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10500077" target="_blank" >RIV/00216208:11130/25:10500077 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/25:10500077

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b~z32Z03dz" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b~z32Z03dz</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00381-025-06881-7" target="_blank" >10.1007/s00381-025-06881-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term prognosis and treatment outcomes in infantile and neonatal brain tumors

Popis výsledku v původním jazyce

PURPOSE: The specifics of biological behavior, anatomical localization, treatment, decision-making, and long-term prognosis in neonatal and infantile intracranial tumors have not been well studied. METHODS: A retrospective monocentric study of patients aged &lt;= 12 months treated for an intracranial tumor over a 23-year period was performed. Data regarding the survival rate according to the tumor histology were evaluated in further detail. RESULTS: A total of 63 patients with a median age of 200 days at the first admission (interquartile range (IQR) = 118-301 days) were analyzed. Most tumors were supratentorial (67.7%). Overall survival according to histopathological subgroups of included tumors was the most favorable in the low-grade glioma subgroup with 1- and 3-year survival of 96% (95% confidence interval [CI] = 88.6-100%) and 88% (95% CI = 76.1-100%), while the 3-year survival for the embryonal tumors subgroup was 15% (95% CI = 4.2-53.4%). Mortality in the cohort reached 42.8% with the median time to death of 6 months (IQR = 1-12 months). CONCLUSION: Infantile and neonatal primary CNS tumors significantly vary from CNS tumors in older pediatric patients both in their localization, distribution of histopathological subtypes, and the presence of mutations specific to these tumors, providing useful therapeutic targets. Brain tumors in children under 1 year of age are scarce compared to other pediatric brain tumors.

Název v anglickém jazyce

Long-term prognosis and treatment outcomes in infantile and neonatal brain tumors

Popis výsledku anglicky

PURPOSE: The specifics of biological behavior, anatomical localization, treatment, decision-making, and long-term prognosis in neonatal and infantile intracranial tumors have not been well studied. METHODS: A retrospective monocentric study of patients aged &lt;= 12 months treated for an intracranial tumor over a 23-year period was performed. Data regarding the survival rate according to the tumor histology were evaluated in further detail. RESULTS: A total of 63 patients with a median age of 200 days at the first admission (interquartile range (IQR) = 118-301 days) were analyzed. Most tumors were supratentorial (67.7%). Overall survival according to histopathological subgroups of included tumors was the most favorable in the low-grade glioma subgroup with 1- and 3-year survival of 96% (95% confidence interval [CI] = 88.6-100%) and 88% (95% CI = 76.1-100%), while the 3-year survival for the embryonal tumors subgroup was 15% (95% CI = 4.2-53.4%). Mortality in the cohort reached 42.8% with the median time to death of 6 months (IQR = 1-12 months). CONCLUSION: Infantile and neonatal primary CNS tumors significantly vary from CNS tumors in older pediatric patients both in their localization, distribution of histopathological subtypes, and the presence of mutations specific to these tumors, providing useful therapeutic targets. Brain tumors in children under 1 year of age are scarce compared to other pediatric brain tumors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NU23-08-00460" target="_blank" >NU23-08-00460: Pokročilé zobrazování dětských mozkových nádorů magnetickou rezonancí /PediTuMRI/</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Child&apos;s Nervous System

ISSN

0256-7040

e-ISSN

1433-0350

Svazek periodika

41

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

251

Kód UT WoS článku

001541737900001

EID výsledku v databázi Scopus

2-s2.0-105012278125