Searching for mechanisms that matter in early septic acute kidney injury: an experimental study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10103438" target="_blank" >RIV/00216208:11140/11:10103438 - isvavai.cz</a>

Výsledek na webu

<a href="http://ccforum.com/content/pdf/cc10517.pdf" target="_blank" >http://ccforum.com/content/pdf/cc10517.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/cc10517" target="_blank" >10.1186/cc10517</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Searching for mechanisms that matter in early septic acute kidney injury: an experimental study

Popis výsledku v původním jazyce

In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only poorly understood. We used a unique opportunity to examine dynamic inflammatory, renalhemodynamic, and microvascular changes in two clinically relevant large-animal models of sepsis. Aim was to assess variability in renal responses to sepsis and to identify both hemodynamic and nonhemodynamic mechanisms discriminating individuals with AKI from those in whom AKI did not develop. Observed variability in susceptibility to septic AKI in our models replicates that of human disease. Early abnormal host response accompanied by subsequent uncoupling between systemic and renal vascular resistance appear to be major determinants in the early phase of porcine septic AKI. Nonuniform and modelrelated renal hemodynamic responses unpredictable from systemic changes should be taken into consideration when evaluating interventions in se

Název v anglickém jazyce

Searching for mechanisms that matter in early septic acute kidney injury: an experimental study

Popis výsledku anglicky

In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only poorly understood. We used a unique opportunity to examine dynamic inflammatory, renalhemodynamic, and microvascular changes in two clinically relevant large-animal models of sepsis. Aim was to assess variability in renal responses to sepsis and to identify both hemodynamic and nonhemodynamic mechanisms discriminating individuals with AKI from those in whom AKI did not develop. Observed variability in susceptibility to septic AKI in our models replicates that of human disease. Early abnormal host response accompanied by subsequent uncoupling between systemic and renal vascular resistance appear to be major determinants in the early phase of porcine septic AKI. Nonuniform and modelrelated renal hemodynamic responses unpredictable from systemic changes should be taken into consideration when evaluating interventions in se

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Critical Care [online]

ISSN

1466-609X

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

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EID výsledku v databázi Scopus

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