Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10106113" target="_blank" >RIV/00216208:11140/11:10106113 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/11:10106113

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer

Popis výsledku v původním jazyce

TIMP-1 (tissue inhibitor of metalloproteinases 1) regulates not only extracellular matrix catabolism but the major effect in tumor tissue is promotion of cell growth and anti-apoptotic activity. The aim of our study was to evaluate TIMP-1 plasma levels and tissue TIMP-1 mRNA expression as a prognostic marker in NSCLC patients. Methods: We studied a group of 108 patients with NSCLC who had undergone lung surgery. Quantitative estimation analysis of TIMP-1 mRNA was performed using RT real-time PCR. Quantitative estimation of plasma TIMP-1 protein was performed using ELISA. Results: There was shorter disease free interval (DFI) in NSCLC patients at stage II with a higher expression of TIMP-1 mRNA in tumor tissue (p{0.0001). We found there to be a statisticaly significant relation between TIMP-1 mRNA tumor tissue expression and DFI in SCC (p{0.0001). We also found shorter overall survival (OS) in patients at stages IIIa + IIIb + IV with a higher expression of TIMP-1 mRNA (p=0.0389). We fou

Název v anglickém jazyce

Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer

Popis výsledku anglicky

TIMP-1 (tissue inhibitor of metalloproteinases 1) regulates not only extracellular matrix catabolism but the major effect in tumor tissue is promotion of cell growth and anti-apoptotic activity. The aim of our study was to evaluate TIMP-1 plasma levels and tissue TIMP-1 mRNA expression as a prognostic marker in NSCLC patients. Methods: We studied a group of 108 patients with NSCLC who had undergone lung surgery. Quantitative estimation analysis of TIMP-1 mRNA was performed using RT real-time PCR. Quantitative estimation of plasma TIMP-1 protein was performed using ELISA. Results: There was shorter disease free interval (DFI) in NSCLC patients at stage II with a higher expression of TIMP-1 mRNA in tumor tissue (p{0.0001). We found there to be a statisticaly significant relation between TIMP-1 mRNA tumor tissue expression and DFI in SCC (p{0.0001). We also found shorter overall survival (OS) in patients at stages IIIa + IIIb + IV with a higher expression of TIMP-1 mRNA (p=0.0389). We fou

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NS10230" target="_blank" >NS10230: Racionalizace strategie onkologické léčby radikálně neoperabilních jaterních metastáz kolorektálního karcinomu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

8

Strana od-do

4031-4038

Kód UT WoS článku

000297482000056

EID výsledku v databázi Scopus

—