Ovarian cancer stem cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10124165" target="_blank" >RIV/00216208:11140/12:10124165 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.4149/neo_2012_094" target="_blank" >http://dx.doi.org/10.4149/neo_2012_094</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2012_094" target="_blank" >10.4149/neo_2012_094</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Ovarian cancer stem cells
Popis výsledku v původním jazyce
Because of its semi-solid character in dissemination and growth, advanced ovarian cancer appears to be an excellent in vivo model for studying the cancer stem cell hypothesis. The exact nature of these tumor-initiating cells endowed with the properties of anoikis-resistance and unlimited self-renewal is not clear at present, however. Until now, no universal marker(s) has been found to faithfully isolate (ovarian) cancer stem cells. As these multipotent cells are known to possess highly elaborated effluxsystems for cytotoxic agents, these pump systems have been exploited to outline putative stem cells as a side-population (SP) via dye exclusion analysis. An alterantive is to isolate stem cells based on surface markers. In the Vienna variant of the ovarian cancer cell line A2780 a proof-of-principle model with both a stable SP and a stable ALDH1A1+ cell population was established. Double staining clearly revealed that both cell fractions were not identical. Of note, A2780V cells were ne
Název v anglickém jazyce
Ovarian cancer stem cells
Popis výsledku anglicky
Because of its semi-solid character in dissemination and growth, advanced ovarian cancer appears to be an excellent in vivo model for studying the cancer stem cell hypothesis. The exact nature of these tumor-initiating cells endowed with the properties of anoikis-resistance and unlimited self-renewal is not clear at present, however. Until now, no universal marker(s) has been found to faithfully isolate (ovarian) cancer stem cells. As these multipotent cells are known to possess highly elaborated effluxsystems for cytotoxic agents, these pump systems have been exploited to outline putative stem cells as a side-population (SP) via dye exclusion analysis. An alterantive is to isolate stem cells based on surface markers. In the Vienna variant of the ovarian cancer cell line A2780 a proof-of-principle model with both a stable SP and a stable ALDH1A1+ cell population was established. Double staining clearly revealed that both cell fractions were not identical. Of note, A2780V cells were ne
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neoplasma
ISSN
0028-2685
e-ISSN
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Svazek periodika
59
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
8
Strana od-do
747-755
Kód UT WoS článku
000310820200019
EID výsledku v databázi Scopus
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