Molecular advances in salivary gland pathology and their practical application

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10128113" target="_blank" >RIV/00216208:11140/12:10128113 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mpdhp.2012.08.002" target="_blank" >http://dx.doi.org/10.1016/j.mpdhp.2012.08.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mpdhp.2012.08.002" target="_blank" >10.1016/j.mpdhp.2012.08.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular advances in salivary gland pathology and their practical application

Popis výsledku v původním jazyce

The review summarizes the new findings in salivary gland pathology with particular reference to molecular genetic developments. In particular, newly recognized entities and specific chromosomal translocations associated with salivary gland carcinomas arediscussed. Firstly, there are three types of salivary gland carcinomas which harbour important oncogenic translocations: mucoepidermoid carcinoma with the translocation t(11; 19)(q21; p13) CRTC1-MAML2 (as well as several other less frequent ones), adenoid cystic carcinoma with the translocation t(6; 9)(q22-23; p23-24) MYB-NFIB, and the recently described entity of mammary analogue secretory carcinoma (MASC) characterized by the translocation t(12; 15)(p13; q25) ETV6-NTRK3. Secondly, sclerosing polycystic adenosis was described in 1996 as possibly a salivary counterpart to benign fibrocystic disease of the breast, but recent molecular evidence of clonality suggests it is neoplastic in nature. Finally, new molecular developments in saliv

Název v anglickém jazyce

Molecular advances in salivary gland pathology and their practical application

Popis výsledku anglicky

The review summarizes the new findings in salivary gland pathology with particular reference to molecular genetic developments. In particular, newly recognized entities and specific chromosomal translocations associated with salivary gland carcinomas arediscussed. Firstly, there are three types of salivary gland carcinomas which harbour important oncogenic translocations: mucoepidermoid carcinoma with the translocation t(11; 19)(q21; p13) CRTC1-MAML2 (as well as several other less frequent ones), adenoid cystic carcinoma with the translocation t(6; 9)(q22-23; p23-24) MYB-NFIB, and the recently described entity of mammary analogue secretory carcinoma (MASC) characterized by the translocation t(12; 15)(p13; q25) ETV6-NTRK3. Secondly, sclerosing polycystic adenosis was described in 1996 as possibly a salivary counterpart to benign fibrocystic disease of the breast, but recent molecular evidence of clonality suggests it is neoplastic in nature. Finally, new molecular developments in saliv

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diagnostic Histopathology

ISSN

1756-2317

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

388-396

Kód UT WoS článku

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EID výsledku v databázi Scopus

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