Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10123169" target="_blank" >RIV/00216208:11140/13:10123169 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/49777513:23520/13:43915266 RIV/00669806:_____/13:10123169

Výsledek na webu

<a href="http://www.karger.com/Article/Pdf/339304" target="_blank" >http://www.karger.com/Article/Pdf/339304</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000339304" target="_blank" >10.1159/000339304</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis

Popis výsledku v původním jazyce

Paper summarizes results of our prospective non-randomized study in the field of quantitative histopathological analysis of the abdominal aortic aneurysms. We evaluated samples of 65 AAA pateints and 55 corresponding thrombi, also 6 normal abdominal aortas. Asymptomatic AAAs had more abundant inflammatory infiltrates, lower amounts of PAI-1, a higher number of tPA-positive elements, a greater concentration of VCAM-1 and MMP-2, and a tendency towards decreased collagen content when compared with symptomatic AAAs. Compared with the aneurysmatic aorta, the normal aorta contained less collagen and more elastin, actin, desmin and PAI-1-positive elements; in addition, it was more vascular. Medium-sized AAAs were the most actin and vimentin rich, and large AAAs were the most vascular. Quantitative microscopy seems to offer a new insight into morphology and pathogenesis of AAA. Our results indicate the rupture-prone nature of the asymptomatic AAAs and support the need for AAA screening program

Název v anglickém jazyce

Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis

Popis výsledku anglicky

Paper summarizes results of our prospective non-randomized study in the field of quantitative histopathological analysis of the abdominal aortic aneurysms. We evaluated samples of 65 AAA pateints and 55 corresponding thrombi, also 6 normal abdominal aortas. Asymptomatic AAAs had more abundant inflammatory infiltrates, lower amounts of PAI-1, a higher number of tPA-positive elements, a greater concentration of VCAM-1 and MMP-2, and a tendency towards decreased collagen content when compared with symptomatic AAAs. Compared with the aneurysmatic aorta, the normal aorta contained less collagen and more elastin, actin, desmin and PAI-1-positive elements; in addition, it was more vascular. Medium-sized AAAs were the most actin and vimentin rich, and large AAAs were the most vascular. Quantitative microscopy seems to offer a new insight into morphology and pathogenesis of AAA. Our results indicate the rupture-prone nature of the asymptomatic AAAs and support the need for AAA screening program

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pathobiology : journal of immunopathology, molecular and cellular biology

ISSN

1015-2008

e-ISSN

—

Svazek periodika

80

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

13

Strana od-do

11-23

Kód UT WoS článku

000308125900002

EID výsledku v databázi Scopus

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