Focal histopathological progression of porcine experimental abdominal aortic aneurysm is mitigated by atorvastatin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134390" target="_blank" >RIV/00216208:11140/13:10134390 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/13:10134390

Výsledek na webu

<a href="http://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2013N03A0291" target="_blank" >http://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2013N03A0291</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Focal histopathological progression of porcine experimental abdominal aortic aneurysm is mitigated by atorvastatin

Popis výsledku v původním jazyce

Our aim was to quantify histological postoperative changes of AAA in porcine experimental model of AAA with and without administration of atorvastatin. The AAA was induced by intraaortic infusion of porcine pancreatic elastase and subrenal application ofplastic cuff. The AAA statin group (n=14) received atorvastatin 1 mg/kg daily for 28 days, the other AAA group (n=13) did not. The aortic diameter was measured by ultrasonography. Aortic samples were described using eleven quantitative histological parameters and compared with healthy aortae. There was no difference in aortic diameter between the AAA with statin when compared to AAA without statin. Administration of atorvastatin led to a better postoperative histological condition of the aortic elastinnetwork, preservation of contractile phenotype of vascular smooth muscle, a higher density of vasa vasorum, it prevented thickening of intima and media. The increase in wall thickness in AAA without atorvastatin has not been accompanied

Název v anglickém jazyce

Focal histopathological progression of porcine experimental abdominal aortic aneurysm is mitigated by atorvastatin

Popis výsledku anglicky

Our aim was to quantify histological postoperative changes of AAA in porcine experimental model of AAA with and without administration of atorvastatin. The AAA was induced by intraaortic infusion of porcine pancreatic elastase and subrenal application ofplastic cuff. The AAA statin group (n=14) received atorvastatin 1 mg/kg daily for 28 days, the other AAA group (n=13) did not. The aortic diameter was measured by ultrasonography. Aortic samples were described using eleven quantitative histological parameters and compared with healthy aortae. There was no difference in aortic diameter between the AAA with statin when compared to AAA without statin. Administration of atorvastatin led to a better postoperative histological condition of the aortic elastinnetwork, preservation of contractile phenotype of vascular smooth muscle, a higher density of vasa vasorum, it prevented thickening of intima and media. The increase in wall thickness in AAA without atorvastatin has not been accompanied

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10235" target="_blank" >NS10235: Snaha o farmakologické ovlivnění růstu experimentálně vzniklého aneuryzmatu abdominální aorty u zvířete</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Angiology

ISSN

0392-9590

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

16

Strana od-do

291-306

Kód UT WoS článku

000322750400004

EID výsledku v databázi Scopus

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