Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10138961" target="_blank" >RIV/00216208:11140/13:10138961 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0304394013002759/1-s2.0-S0304394013002759-main.pdf?_tid=63c90cda-097b-11e3-a29c-00000aab0f01&acdnat=1376991311_bdf9283d61c8680bc2d025dc056fbd25" target="_blank" >http://ac.els-cdn.com/S0304394013002759/1-s2.0-S0304394013002759-main.pdf?_tid=63c90cda-097b-11e3-a29c-00000aab0f01&acdnat=1376991311_bdf9283d61c8680bc2d025dc056fbd25</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2013.03.034" target="_blank" >10.1016/j.neulet.2013.03.034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice

Popis výsledku v původním jazyce

DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO r

Název v anglickém jazyce

Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice

Popis výsledku anglicky

DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO r

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedicínské centrum Lékařské fakulty v Plzni</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Letters

ISSN

0304-3940

e-ISSN

—

Svazek periodika

543

Číslo periodika v rámci svazku

may

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

4

Strana od-do

142-145

Kód UT WoS článku

000319646000028

EID výsledku v databázi Scopus

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