Chromophobe renal cell carcinoma - chromosomal aberration variability and its relation to Paner grading system: an array CGH and FISH analysis of 37 cases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10144139" target="_blank" >RIV/00216208:11140/13:10144139 - isvavai.cz</a>

Výsledek na webu

<a href="http://download.springer.com/static/pdf/208/art%253A10.1007%252Fs00428-013-1457-6.pdf?auth66=1385022674_00330552c54391337ac47cee6856836b&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/208/art%253A10.1007%252Fs00428-013-1457-6.pdf?auth66=1385022674_00330552c54391337ac47cee6856836b&ext=.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00428-013-1457-6" target="_blank" >10.1007/s00428-013-1457-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chromophobe renal cell carcinoma - chromosomal aberration variability and its relation to Paner grading system: an array CGH and FISH analysis of 37 cases

Popis výsledku v původním jazyce

Genetically, chromophobe renal cell carcinoma (ChRCC) is characterized by multiple chromosomal changes, especially losses. The most common losses include chromosomes 1, 2, 6, 10, 13, 17, and 21. The Fuhrman grading system lacks prognostic relevance for ChRCC, and recently, a new grading system for ChRCC was proposed by Paner. The objective of this study was to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of ChRCCs and relate these findings to the Paner grading system (PGS). A large cohort of ChRCC was reviewed and graded according to the PGS. All the cases were reevaluated and separated into groups according to their PGS. The final study set was 37 patients. ChRCCs were divided into PG 1-3, sarcomatoid, and aggressive groups. "Aggressive ChRCCs" were designated cases with known metastatic activity, local recurrence, aggressive growth to the adjacent organs, or invasive growth into the renal sinus (with/without angioinvasion). Sarcomatoid tumors we

Název v anglickém jazyce

Chromophobe renal cell carcinoma - chromosomal aberration variability and its relation to Paner grading system: an array CGH and FISH analysis of 37 cases

Popis výsledku anglicky

Genetically, chromophobe renal cell carcinoma (ChRCC) is characterized by multiple chromosomal changes, especially losses. The most common losses include chromosomes 1, 2, 6, 10, 13, 17, and 21. The Fuhrman grading system lacks prognostic relevance for ChRCC, and recently, a new grading system for ChRCC was proposed by Paner. The objective of this study was to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of ChRCCs and relate these findings to the Paner grading system (PGS). A large cohort of ChRCC was reviewed and graded according to the PGS. All the cases were reevaluated and separated into groups according to their PGS. The final study set was 37 patients. ChRCCs were divided into PG 1-3, sarcomatoid, and aggressive groups. "Aggressive ChRCCs" were designated cases with known metastatic activity, local recurrence, aggressive growth to the adjacent organs, or invasive growth into the renal sinus (with/without angioinvasion). Sarcomatoid tumors we

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedicínské centrum Lékařské fakulty v Plzni</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Virchows Archiv : an international journal of pathology

ISSN

0945-6317

e-ISSN

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Svazek periodika

463

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

563-573

Kód UT WoS článku

000325392300009

EID výsledku v databázi Scopus

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