Possible prooxidant effect of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor (AT1) antagonists in neural tissue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10193031" target="_blank" >RIV/00216208:11140/13:10193031 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Possible prooxidant effect of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor (AT1) antagonists in neural tissue

Popis výsledku v původním jazyce

Angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1) antagonists (ARBs, sartans) are widely used for treatment of cardiovascular diseases. Many findings suggest they also have a potent ability to protect tissues againstthe damage associated with oxidative stress. Contrary to these results, our experiments show ACE inhibitors and sartans may have some prooxidant activity, mainly in neural tissue. Male Wistar rats were treated orally once daily for 3 days with captoril(50 mg/kg), losartan (20 mg/kg), or telmisartan (10 mg/kg). All substances were given by gastric gavages, dispersed in methylcellulose. Animals in the control group received methylcellulose only. On the fourth day, parameters of oxidative state: lipid peroxidation (thiobarbituric acid reactive substances), reduced glutathione (GSH) and activity of antioxidant enzymes glutathione peroxidase and glutathione reductase were estimated in liver and brain homogenates. Administration of captopri

Název v anglickém jazyce

Possible prooxidant effect of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor (AT1) antagonists in neural tissue

Popis výsledku anglicky

Angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1) antagonists (ARBs, sartans) are widely used for treatment of cardiovascular diseases. Many findings suggest they also have a potent ability to protect tissues againstthe damage associated with oxidative stress. Contrary to these results, our experiments show ACE inhibitors and sartans may have some prooxidant activity, mainly in neural tissue. Male Wistar rats were treated orally once daily for 3 days with captoril(50 mg/kg), losartan (20 mg/kg), or telmisartan (10 mg/kg). All substances were given by gastric gavages, dispersed in methylcellulose. Animals in the control group received methylcellulose only. On the fourth day, parameters of oxidative state: lipid peroxidation (thiobarbituric acid reactive substances), reduced glutathione (GSH) and activity of antioxidant enzymes glutathione peroxidase and glutathione reductase were estimated in liver and brain homogenates. Administration of captopri

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plzeňský lékařský sborník

ISSN

0551-1038

e-ISSN

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Svazek periodika

2013

Číslo periodika v rámci svazku

79

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

43-48

Kód UT WoS článku

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EID výsledku v databázi Scopus

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