Markers of metastatic bone process - test of multiplex assay

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10193077" target="_blank" >RIV/00216208:11140/13:10193077 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/13:10193077

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Markers of metastatic bone process - test of multiplex assay

Popis výsledku v původním jazyce

A multiplex panel for the measurement of serum levels, including osteoprotegerin, osteopontin, osteocalcin, parathormon and leptin, was tested in a group of cancer patients with metastatic disease, and also in healthy controls. Methods: Cancer cases weredivided into one group with an occurrence of bone metastases and into one group without bone metastases. Serum levels of markers of biologic activity were measured using Human Bone Panel for multiplex xMAP technology. Additionaly, routine serum bone markers (PINP, PIIINP, ostase, ICTP and 25-hydroxyvitamin D) were assessed with routine immunoassays in cancer groups. Results:In comparison to controls, both cancer groups were observed to have higher levels of osteoprotegerin and lower levels of osteocalcin. The bone metastatic group had higher levels of PIIINP and ostase than the non-bonemetastatic group. 3 of 4 patients with multiple bone metastases had values above the set normal value for both osteoprotegerin and osteopontin in compar

Název v anglickém jazyce

Markers of metastatic bone process - test of multiplex assay

Popis výsledku anglicky

A multiplex panel for the measurement of serum levels, including osteoprotegerin, osteopontin, osteocalcin, parathormon and leptin, was tested in a group of cancer patients with metastatic disease, and also in healthy controls. Methods: Cancer cases weredivided into one group with an occurrence of bone metastases and into one group without bone metastases. Serum levels of markers of biologic activity were measured using Human Bone Panel for multiplex xMAP technology. Additionaly, routine serum bone markers (PINP, PIIINP, ostase, ICTP and 25-hydroxyvitamin D) were assessed with routine immunoassays in cancer groups. Results:In comparison to controls, both cancer groups were observed to have higher levels of osteoprotegerin and lower levels of osteocalcin. The bone metastatic group had higher levels of PIIINP and ostase than the non-bonemetastatic group. 3 of 4 patients with multiple bone metastases had values above the set normal value for both osteoprotegerin and osteopontin in compar

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13655" target="_blank" >NT13655: Biomarkery kostní metastatické nemoci</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plzeňský lékařský sborník

ISSN

0551-1038

e-ISSN

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Svazek periodika

2013

Číslo periodika v rámci svazku

79

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

9-18

Kód UT WoS článku

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EID výsledku v databázi Scopus

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