Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke : Results From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10173982" target="_blank" >RIV/00216208:11140/14:10173982 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/14:00060926 RIV/00669806:_____/14:10173982

Výsledek na webu

<a href="http://stroke.ahajournals.org/content/45/1/176" target="_blank" >http://stroke.ahajournals.org/content/45/1/176</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/STROKEAHA.113.002133" target="_blank" >10.1161/STROKEAHA.113.002133</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke : Results From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Popis výsledku v původním jazyce

Background and Purpose-Temporal variations of thrombolysis delivery and their influence on outcome have been reported with controversial results. In this large cohort study, we evaluated whether thrombolytic treatment has a within-day and weekly variability corresponding to circadian and weekly patterns of ischemic stroke onset, and whether these have impact on clinical outcome. Methods-We retrospectively analyzed patients with acute ischemic stroke receiving intravenous alteplase, prospectively included in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register. Patients were grouped by treatment on day hours (08:00-19:59) or night hours (20:00-07:59) and treatment on weekdays and weekends. For each subgroup, we analyzed frequency of thrombolytic treatments, time intervals, and outcomes (3-month modified Rankin Scale score 0-2 as good functional outcome, mortality, symptomatic intracerebral hemorrhage). Results-We included 21 513 patients. Considerin

Název v anglickém jazyce

Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke : Results From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Popis výsledku anglicky

Background and Purpose-Temporal variations of thrombolysis delivery and their influence on outcome have been reported with controversial results. In this large cohort study, we evaluated whether thrombolytic treatment has a within-day and weekly variability corresponding to circadian and weekly patterns of ischemic stroke onset, and whether these have impact on clinical outcome. Methods-We retrospectively analyzed patients with acute ischemic stroke receiving intravenous alteplase, prospectively included in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register. Patients were grouped by treatment on day hours (08:00-19:59) or night hours (20:00-07:59) and treatment on weekdays and weekends. For each subgroup, we analyzed frequency of thrombolytic treatments, time intervals, and outcomes (3-month modified Rankin Scale score 0-2 as good functional outcome, mortality, symptomatic intracerebral hemorrhage). Results-We included 21 513 patients. Considerin

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stroke

ISSN

0039-2499

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

176-184

Kód UT WoS článku

000328823400038

EID výsledku v databázi Scopus

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