Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10281769" target="_blank" >RIV/00216208:11140/14:10281769 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/gcc.22195/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/gcc.22195/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/gcc.22195" target="_blank" >10.1002/gcc.22195</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin

Popis výsledku v původním jazyce

Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, as they appear to have significant overlap, but also clinicopathologic differencese. As many salivary carcinomas harbor recurrent translocations, paired-end RNA sequencing and FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs and two PlGAs. Validated rearrangements were then screened by fluorescence in situ hybridization (FISH) in 60 case. Histologic classification was performed without knowledge of fuion status and included: 21 CAMSG, 18 classic PlGA, and 21 with "mixed/indeterminate" features.

Název v anglickém jazyce

Novel PRKD Gene Rearrangements and Variant Fusions in Cribriform Adenocarcinoma of Salivary Gland Origin

Popis výsledku anglicky

Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, as they appear to have significant overlap, but also clinicopathologic differencese. As many salivary carcinomas harbor recurrent translocations, paired-end RNA sequencing and FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs and two PlGAs. Validated rearrangements were then screened by fluorescence in situ hybridization (FISH) in 60 case. Histologic classification was performed without knowledge of fuion status and included: 21 CAMSG, 18 classic PlGA, and 21 with "mixed/indeterminate" features.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genes Chromosomes and Cancer [online]

ISSN

1098-2264

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

HU - Maďarsko

Počet stran výsledku

12

Strana od-do

845-856

Kód UT WoS článku

000342157900005

EID výsledku v databázi Scopus

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