Chromophobe renal cell carcinoma with neuroendocrine differentiation / morpohology: a clinicopathological and genetic study of three cases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10283815" target="_blank" >RIV/00216208:11140/14:10283815 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/14:10283815

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S2214330014200174#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2214330014200174#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ehpc.2014.08.003" target="_blank" >10.1016/j.ehpc.2014.08.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chromophobe renal cell carcinoma with neuroendocrine differentiation / morpohology: a clinicopathological and genetic study of three cases

Popis výsledku v původním jazyce

Chromophobe renal cell carcinoma (ChRCC) with neuroendocrine differentiation/ morphology (NED/NEM) is exceedingly rare. We present three cases of ChRCC with NED/NEM, two of which showed positivity for neuroendocrine markers on immunohistochemical analysis. Patients ranged in age from 49 to 79 years (mean: 64.3 years). One of the three patients died of metastatic disease to multiple organs. Of the remaining two patients, one is currently alive without disease and the other is alive with disease. Histologically, all three tumors were composed of conventional ChRCC and NEM showed glandular and rosette formation. Immunohistochemically, tumor cells were positive for CK7, KAI1, E-cadherin, and c-kit in both ChRCC and neuroendocrine areas in three cases. CD56and synaptophysin immunoreactivity were detected in two cases; in only the neuroendocrine area in one case and in both components in the other. Neuroendocrine granules were ultrastructurally observed at both neuroendocrine and convention

Název v anglickém jazyce

Chromophobe renal cell carcinoma with neuroendocrine differentiation / morpohology: a clinicopathological and genetic study of three cases

Popis výsledku anglicky

Chromophobe renal cell carcinoma (ChRCC) with neuroendocrine differentiation/ morphology (NED/NEM) is exceedingly rare. We present three cases of ChRCC with NED/NEM, two of which showed positivity for neuroendocrine markers on immunohistochemical analysis. Patients ranged in age from 49 to 79 years (mean: 64.3 years). One of the three patients died of metastatic disease to multiple organs. Of the remaining two patients, one is currently alive without disease and the other is alive with disease. Histologically, all three tumors were composed of conventional ChRCC and NEM showed glandular and rosette formation. Immunohistochemically, tumor cells were positive for CK7, KAI1, E-cadherin, and c-kit in both ChRCC and neuroendocrine areas in three cases. CD56and synaptophysin immunoreactivity were detected in two cases; in only the neuroendocrine area in one case and in both components in the other. Neuroendocrine granules were ultrastructurally observed at both neuroendocrine and convention

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Human Pathology

ISSN

0046-8177

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

31-39

Kód UT WoS článku

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EID výsledku v databázi Scopus

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