Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10143954" target="_blank" >RIV/00216208:11140/15:10143954 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/15:00010134

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.aller.2013.06.009" target="_blank" >http://dx.doi.org/10.1016/j.aller.2013.06.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aller.2013.06.009" target="_blank" >10.1016/j.aller.2013.06.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens

Popis výsledku v původním jazyce

Background Nasal inflammation in allergic rhinitis enhances bronchial Th2 driven inflammation and development of asthma. We assessed bronchial inflammation induced by natural allergen exposure during pollen season in patients with pollinosis with or without asthma to show the intensity of inflammation in asthma and rhinitis and possible persistence of inflammation in periods without allergen exposure. Methods Sputum was induced in 52 patients with seasonal allergic rhinitis without asthma, 38 patients with seasonal allergic rhinitis and seasonal asthma and 23 healthy volunteers. Sampling was performed 6-8 weeks before the expected beginning of symptoms, during symptomatic period and 6-8 weeks after the end of symptoms. Sputum ECP was measured by meansof chemiluminiscent immunometric assay and sputum cell counts were assessed by classical staining and immunocytochemistry. Results Sputum eosinophils were on the whole higher in both asthma and rhinitis compared to controls (p < 0.001, p

Název v anglickém jazyce

Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens

Popis výsledku anglicky

Background Nasal inflammation in allergic rhinitis enhances bronchial Th2 driven inflammation and development of asthma. We assessed bronchial inflammation induced by natural allergen exposure during pollen season in patients with pollinosis with or without asthma to show the intensity of inflammation in asthma and rhinitis and possible persistence of inflammation in periods without allergen exposure. Methods Sputum was induced in 52 patients with seasonal allergic rhinitis without asthma, 38 patients with seasonal allergic rhinitis and seasonal asthma and 23 healthy volunteers. Sampling was performed 6-8 weeks before the expected beginning of symptoms, during symptomatic period and 6-8 weeks after the end of symptoms. Sputum ECP was measured by meansof chemiluminiscent immunometric assay and sputum cell counts were assessed by classical staining and immunocytochemistry. Results Sputum eosinophils were on the whole higher in both asthma and rhinitis compared to controls (p < 0.001, p

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Allergologia et Immunopathologia

ISSN

0301-0546

e-ISSN

—

Svazek periodika

43

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

7

Strana od-do

3-9

Kód UT WoS článku

000349067400001

EID výsledku v databázi Scopus

2-s2.0-84921540364