Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10293644" target="_blank" >RIV/00216208:11140/15:10293644 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s00428-014-1701-8" target="_blank" >http://dx.doi.org/10.1007/s00428-014-1701-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-014-1701-8" target="_blank" >10.1007/s00428-014-1701-8</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement
Popis výsledku v původním jazyce
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour that harbours the recurrent ETV6-NTRK3 translocation. This is the first series of MASC cases identified in the historic cohort of carcinomas of salivary glands withclinical/pathological correlation and follow-up data. We reviewed 183 primary carcinomas of major and minor salivary glands resected at the Medical University of Gdańsk, Poland, between 1992 and 2012. Based on morphology and immunohistochemistry, casessuspiciou for MASC were selected, and the diagnosis was confirmed by fluorescence in situ hybridization (FISH) for ETV6 rearrangement and by RT-PCR for the ETV6-NTRK3 fusion transcript. Seven carcinomasmet the criteria ofMASC, as they exhibited a typicalappearance with solid/microcystic and papillary architecture and intraluminal secretions, and cells completely evoid of basophilic cytoplasmic zymogen granules indicative f true acinar differentiation. The only paediatric case was n unen
Název v anglickém jazyce
Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement
Popis výsledku anglicky
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour that harbours the recurrent ETV6-NTRK3 translocation. This is the first series of MASC cases identified in the historic cohort of carcinomas of salivary glands withclinical/pathological correlation and follow-up data. We reviewed 183 primary carcinomas of major and minor salivary glands resected at the Medical University of Gdańsk, Poland, between 1992 and 2012. Based on morphology and immunohistochemistry, casessuspiciou for MASC were selected, and the diagnosis was confirmed by fluorescence in situ hybridization (FISH) for ETV6 rearrangement and by RT-PCR for the ETV6-NTRK3 fusion transcript. Seven carcinomasmet the criteria ofMASC, as they exhibited a typicalappearance with solid/microcystic and papillary architecture and intraluminal secretions, and cells completely evoid of basophilic cytoplasmic zymogen granules indicative f true acinar differentiation. The only paediatric case was n unen
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FP - Ostatní lékařské obory
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Virchows Archiv : an international journal of pathology
ISSN
0945-6317
e-ISSN
—
Svazek periodika
466
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
10
Strana od-do
245-254
Kód UT WoS článku
000351145000002
EID výsledku v databázi Scopus
2-s2.0-84925519941