Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10294675" target="_blank" >RIV/00216208:11140/15:10294675 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.5114/pjp.2015.51147" target="_blank" >http://dx.doi.org/10.5114/pjp.2015.51147</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5114/pjp.2015.51147" target="_blank" >10.5114/pjp.2015.51147</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects
Popis výsledku v původním jazyce
Rhabdoid morphology in renal cell carcinoma (RCC) may, like sarcomatoid change, be perceived as a type of dedifferentiation, and is a poor prognostic factor. Histologically, rhabdoid neoplastic cells are round to polygonal cells with globular eosinophilic cytoplasmic inclusions and eccentric vesicular nuclei and enlarged nucleoli. All types of RCC, including clear cell, papillary, chromophobe, collecting duct carcinoma, renal medullary carcinoma, acquired cystic disease-associated RCC, ALK-positive renal cancer and unclassified RCC, may display a variably prominent rhabdoid phenotype. Immunohistochemically, the cytoplasm of rhabdoid cells shows positivity for vimentin and/or cytokeratin. Ultrastructurally, cytoplasmic whorls/aggregates of intermediatefilaments correspond to light microscopically observed inclusions. Genetically, a previous report suggests that combined loss of BAP1 and PBRM1 may be associated with rhabdoid morphology. As with sarcomatoid change, pathologists should de
Název v anglickém jazyce
Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects
Popis výsledku anglicky
Rhabdoid morphology in renal cell carcinoma (RCC) may, like sarcomatoid change, be perceived as a type of dedifferentiation, and is a poor prognostic factor. Histologically, rhabdoid neoplastic cells are round to polygonal cells with globular eosinophilic cytoplasmic inclusions and eccentric vesicular nuclei and enlarged nucleoli. All types of RCC, including clear cell, papillary, chromophobe, collecting duct carcinoma, renal medullary carcinoma, acquired cystic disease-associated RCC, ALK-positive renal cancer and unclassified RCC, may display a variably prominent rhabdoid phenotype. Immunohistochemically, the cytoplasm of rhabdoid cells shows positivity for vimentin and/or cytokeratin. Ultrastructurally, cytoplasmic whorls/aggregates of intermediatefilaments correspond to light microscopically observed inclusions. Genetically, a previous report suggests that combined loss of BAP1 and PBRM1 may be associated with rhabdoid morphology. As with sarcomatoid change, pathologists should de
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FP - Ostatní lékařské obory
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Polish Journal of Pathology
ISSN
1233-9687
e-ISSN
—
Svazek periodika
66
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
PL - Polská republika
Počet stran výsledku
6
Strana od-do
3-8
Kód UT WoS článku
000354418400002
EID výsledku v databázi Scopus
2-s2.0-84929409541