Histology of grafts implanted to carotid artery in rabbit

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10298039" target="_blank" >RIV/00216208:11140/15:10298039 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Histology of grafts implanted to carotid artery in rabbit

Popis výsledku v původním jazyce

The aim of the histological study was to evaluate the cellular infiltration and wall composition of bioengineered aortic grafts after 10 weeks and after 6 months of implantation as a carotid artery bypass in rabbit. The grafts were not suitable for routine histological processing and they were partially disintegrated during embedding and sectioning. The grafts seemed to be well tolerated and no adverse tissue reaction was found. However, the grafts did not offer sufficient support and differentiation niches for cells infiltrating the grafts. The thin-walled grafts were never populated by substantial amounts of cells that would be able to produce the usual connective tissue matrix collagen and elastin fibres or to form the regular tunica media of elastic arteries with concentric layers of elastin, vascular smooth muscle cells, and collagen (Shadwick, 1999). From histological point of view, the grafts did not develop structural similarities with carotid artery.

Název v anglickém jazyce

Histology of grafts implanted to carotid artery in rabbit

Popis výsledku anglicky

The aim of the histological study was to evaluate the cellular infiltration and wall composition of bioengineered aortic grafts after 10 weeks and after 6 months of implantation as a carotid artery bypass in rabbit. The grafts were not suitable for routine histological processing and they were partially disintegrated during embedding and sectioning. The grafts seemed to be well tolerated and no adverse tissue reaction was found. However, the grafts did not offer sufficient support and differentiation niches for cells infiltrating the grafts. The thin-walled grafts were never populated by substantial amounts of cells that would be able to produce the usual connective tissue matrix collagen and elastin fibres or to form the regular tunica media of elastic arteries with concentric layers of elastin, vascular smooth muscle cells, and collagen (Shadwick, 1999). From histological point of view, the grafts did not develop structural similarities with carotid artery.

Druh

V_souhrn - Souhrnná výzkumná zpráva

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

Počet stran výsledku

11

Místo vydání

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Název nakladatele resp. objednatele

Technická univerzita v Liberci

Verze

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