Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10311894" target="_blank" >RIV/00216208:11140/15:10311894 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/15:00059387

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12882-015-0141-2" target="_blank" >http://dx.doi.org/10.1186/s12882-015-0141-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12882-015-0141-2" target="_blank" >10.1186/s12882-015-0141-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

Popis výsledku v původním jazyce

Background: Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects. Methods: The mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1,FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant recipients before and 7, 14, 21, 28, 60, 90 days, 6 months, and 12 months after KTx. Patients were treated with calcineurin inhibitor-based triple immunosuppression and induction with rabbit antithymocyte globulin (rATG, n = 24), basiliximab (n = 17), or without induction (no-induction, n = 19). A generalized linear mixed model with gamma distribution for repeated measures, adjusted for rejection, recipient/donor age and delayed graft function, was used for statistical analysis. Results: rATG treatment caused an intense reduction in all T cell type population and natural killer (NK) cells within 7 da

Název v anglickém jazyce

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

Popis výsledku anglicky

Background: Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects. Methods: The mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1,FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant recipients before and 7, 14, 21, 28, 60, 90 days, 6 months, and 12 months after KTx. Patients were treated with calcineurin inhibitor-based triple immunosuppression and induction with rabbit antithymocyte globulin (rATG, n = 24), basiliximab (n = 17), or without induction (no-induction, n = 19). A generalized linear mixed model with gamma distribution for repeated measures, adjusted for rejection, recipient/donor age and delayed graft function, was used for statistical analysis. Results: rATG treatment caused an intense reduction in all T cell type population and natural killer (NK) cells within 7 da

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Nephrology

ISSN

1471-2369

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

19 August 2015

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000359616400002

EID výsledku v databázi Scopus

2-s2.0-84939432231