Molecular genetic data favoring a sequential clonal transformation of a large B cell lymphoma into an anaplastic large T cell lymphoma, ALK-negative

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10316433" target="_blank" >RIV/00216208:11140/15:10316433 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s12308-015-0245-4" target="_blank" >http://dx.doi.org/10.1007/s12308-015-0245-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12308-015-0245-4" target="_blank" >10.1007/s12308-015-0245-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular genetic data favoring a sequential clonal transformation of a large B cell lymphoma into an anaplastic large T cell lymphoma, ALK-negative

Popis výsledku v původním jazyce

A large B cell lymphoma with monoclonal rearranged, sequentially identical TRG and near identical IGH genes twice relapsed as an anaplastic large T cell lymphoma, ALK-negative. While these IGH and TRG rearrangements were also detected in both relapsed lymphomas, near identical IGK rearrangement was present in the primary and the first relapse, though not in the second relapse, and identical TRB rearrangement was detected only in both relapses, not in the primary. Normal T lymphocytes were the only T cell component found in the primary lymphoma, thus excluding a possibility that the primary lymphoma was a classic composite B and T cell lymphoma. Our data, particularly, the presence of sequentially identical monoclonal TRG and near identical IGH rearrangement in the primary and both relapsed lymphomas, favor a gradual transformation of a B cell lymphoma into a T cell lymphoma. In our opinion, this previously not described phenomenon likely represents a composite lymphoma in statu nascend

Název v anglickém jazyce

Molecular genetic data favoring a sequential clonal transformation of a large B cell lymphoma into an anaplastic large T cell lymphoma, ALK-negative

Popis výsledku anglicky

A large B cell lymphoma with monoclonal rearranged, sequentially identical TRG and near identical IGH genes twice relapsed as an anaplastic large T cell lymphoma, ALK-negative. While these IGH and TRG rearrangements were also detected in both relapsed lymphomas, near identical IGK rearrangement was present in the primary and the first relapse, though not in the second relapse, and identical TRB rearrangement was detected only in both relapses, not in the primary. Normal T lymphocytes were the only T cell component found in the primary lymphoma, thus excluding a possibility that the primary lymphoma was a classic composite B and T cell lymphoma. Our data, particularly, the presence of sequentially identical monoclonal TRG and near identical IGH rearrangement in the primary and both relapsed lymphomas, favor a gradual transformation of a B cell lymphoma into a T cell lymphoma. In our opinion, this previously not described phenomenon likely represents a composite lymphoma in statu nascend

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Hematopathology [online]

ISSN

1865-5785

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

243-253

Kód UT WoS článku

000365543600006

EID výsledku v databázi Scopus

2-s2.0-84958766086