Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10324237" target="_blank" >RIV/00216208:11140/16:10324237 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s13000-016-0505-3" target="_blank" >http://dx.doi.org/10.1186/s13000-016-0505-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13000-016-0505-3" target="_blank" >10.1186/s13000-016-0505-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease

Popis výsledku v původním jazyce

In summary, approximately one third of BD lesions in our Czech (Caucasian Eastern European) population are HPV-associated. In the HPV-positive lesions β- HPV genotypes predominated, although high- and low-risk mucosal HPV types were detected in a significant proportion of cases. The presence of the p16- expression, koilocyte-like change or papillomatosis is not predictive for the presence of neither α-HPV types nor β-HPV types in extragenital/extraungual Bowen's disease. Our study further supports the hypothesis that HPV infection might serve as an important co-factor in the carcinogenesis of BD and cSCC and identifies HPV 9 as a possibly significant β-HPV genotype with respect to mixed β-HPV infections and keratinocyte carcinogenesis.

Název v anglickém jazyce

Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease

Popis výsledku anglicky

In summary, approximately one third of BD lesions in our Czech (Caucasian Eastern European) population are HPV-associated. In the HPV-positive lesions β- HPV genotypes predominated, although high- and low-risk mucosal HPV types were detected in a significant proportion of cases. The presence of the p16- expression, koilocyte-like change or papillomatosis is not predictive for the presence of neither α-HPV types nor β-HPV types in extragenital/extraungual Bowen's disease. Our study further supports the hypothesis that HPV infection might serve as an important co-factor in the carcinogenesis of BD and cSCC and identifies HPV 9 as a possibly significant β-HPV genotype with respect to mixed β-HPV infections and keratinocyte carcinogenesis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diagnostic Pathology

ISSN

1746-1596

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000379298800001

EID výsledku v databázi Scopus

2-s2.0-84975690964