Hormone receptor status of contralateral breast cancers: analysis of data from the US SEER population-based registries

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10360779" target="_blank" >RIV/00216208:11140/17:10360779 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/17:10360779

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs12282-016-0716-1" target="_blank" >https://link.springer.com/article/10.1007%2Fs12282-016-0716-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12282-016-0716-1" target="_blank" >10.1007/s12282-016-0716-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hormone receptor status of contralateral breast cancers: analysis of data from the US SEER population-based registries

Popis výsledku v původním jazyce

Background Women diagnosed with breast cancer display higher propensity to develop second primary cancer in the contralateral breast (CBC). Identification of patients with increased risk of CBC and understanding relationships between hormone receptor (HR) statuses of the first and second breast cancers is desirable for endocrine-based prevention strategies. Methods Using 1992-2012 data from 13 SEER registries, the risk of developing CBC was determined as ratio of observed and expected second breast cancers (SIR). Association between HR statuses was examined by exploratory data analysis and multivariable logistic regression. Results: Women with ER-positive and ER-negative breast cancers have increased risk of developing CBC with SIR values 2.09 (CI 95 = 1.97-2.21) and 2.40 (CI 95 = 2.18-2.63), respectively. ER statuses of the CBC are moderately positively associated. In metachronous CBC, most cases with ER-positive first cancers had ER-positive second breast cancers (81.6 %; CI 95 = 80.2-82.9 %); however, considerable proportion of cases with ER-negative first cancers had ER-positive second cancers (48.8 %; CI 95 = 46.2-51.4 %). Conclusions Some women with ER-negative breast cancers may benefit from endocrine-based prevention of ER-positive CBC.

Název v anglickém jazyce

Hormone receptor status of contralateral breast cancers: analysis of data from the US SEER population-based registries

Popis výsledku anglicky

Background Women diagnosed with breast cancer display higher propensity to develop second primary cancer in the contralateral breast (CBC). Identification of patients with increased risk of CBC and understanding relationships between hormone receptor (HR) statuses of the first and second breast cancers is desirable for endocrine-based prevention strategies. Methods Using 1992-2012 data from 13 SEER registries, the risk of developing CBC was determined as ratio of observed and expected second breast cancers (SIR). Association between HR statuses was examined by exploratory data analysis and multivariable logistic regression. Results: Women with ER-positive and ER-negative breast cancers have increased risk of developing CBC with SIR values 2.09 (CI 95 = 1.97-2.21) and 2.40 (CI 95 = 2.18-2.63), respectively. ER statuses of the CBC are moderately positively associated. In metachronous CBC, most cases with ER-positive first cancers had ER-positive second breast cancers (81.6 %; CI 95 = 80.2-82.9 %); however, considerable proportion of cases with ER-negative first cancers had ER-positive second cancers (48.8 %; CI 95 = 46.2-51.4 %). Conclusions Some women with ER-negative breast cancers may benefit from endocrine-based prevention of ER-positive CBC.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Breast Cancer

ISSN

1340-6868

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

11

Strana od-do

400-410

Kód UT WoS článku

000399688900009

EID výsledku v databázi Scopus

2-s2.0-84981263995