Spectrum of changes in anogenital mammary-like glands in primary extramammary (anogenital) Paget disease and their possible role in the pathogenesis of the disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10362203" target="_blank" >RIV/00216208:11140/17:10362203 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1097/PAS.0000000000000857" target="_blank" >http://dx.doi.org/10.1097/PAS.0000000000000857</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000000857" target="_blank" >10.1097/PAS.0000000000000857</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Spectrum of changes in anogenital mammary-like glands in primary extramammary (anogenital) Paget disease and their possible role in the pathogenesis of the disease
Popis výsledku v původním jazyce
To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). In all cases, lesions involved the vulva and in 1 patient the perianal skin was affected. Histopathologically, AGMLG manifested changes identical to columnar cell change (CCC) (87.1%), usual ductal hyperplasia (22.6%), columnar cell hyperplasia (CCH) (9.7%), oxyphilic (apocrine) metaplasia (6.5%), and atypical duct hyperplasia (3.2%). Four cases (12.9%), in addition to intraepidermal carcinoma, harbored invasive carcinoma. In all 4 of these, AGMLG displayed a range of alterations including ductal carcinoma in situ, CCC, and CCH. Three further cases (9.7%) showed ductal carcinoma in situ without any definite invasive carcinoma. Colonization of AGMLG by neoplastic Paget ells was noted in 6 cases. As CCC and CCH may be encountered n normal AGMLG, these alterations are unlikely to play a ignificant role in the pathogenesis of the disease. However, by nalogy with mammary Paget disease, rare cases of primary EMPD ay originate in AGMLG with a subsequent upward migration of he neoplastic cells into the epidermis and possible later breach hrough the basal membrane. Usual ductal hyperplasia and atypical uct hyperplasia can then be regarded as earlier precursor lesions, inking both ends of the spectrum.
Název v anglickém jazyce
Spectrum of changes in anogenital mammary-like glands in primary extramammary (anogenital) Paget disease and their possible role in the pathogenesis of the disease
Popis výsledku anglicky
To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). In all cases, lesions involved the vulva and in 1 patient the perianal skin was affected. Histopathologically, AGMLG manifested changes identical to columnar cell change (CCC) (87.1%), usual ductal hyperplasia (22.6%), columnar cell hyperplasia (CCH) (9.7%), oxyphilic (apocrine) metaplasia (6.5%), and atypical duct hyperplasia (3.2%). Four cases (12.9%), in addition to intraepidermal carcinoma, harbored invasive carcinoma. In all 4 of these, AGMLG displayed a range of alterations including ductal carcinoma in situ, CCC, and CCH. Three further cases (9.7%) showed ductal carcinoma in situ without any definite invasive carcinoma. Colonization of AGMLG by neoplastic Paget ells was noted in 6 cases. As CCC and CCH may be encountered n normal AGMLG, these alterations are unlikely to play a ignificant role in the pathogenesis of the disease. However, by nalogy with mammary Paget disease, rare cases of primary EMPD ay originate in AGMLG with a subsequent upward migration of he neoplastic cells into the epidermis and possible later breach hrough the basal membrane. Usual ductal hyperplasia and atypical uct hyperplasia can then be regarded as earlier precursor lesions, inking both ends of the spectrum.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30216 - Dermatology and venereal diseases
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
The American Journal of Surgical Pathology
ISSN
0147-5185
e-ISSN
—
Svazek periodika
41
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
1053-1058
Kód UT WoS článku
000405558300006
EID výsledku v databázi Scopus
2-s2.0-85020714728