Cardiovascular Models: Heart Secondarily Affected by Disease (Diabetes Mellitus, Renal Failure, Dysfunctional Sympathetic Innervation)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10362381" target="_blank" >RIV/00216208:11140/17:10362381 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.elsevier.com/books/animal-models-for-the-study-of-human-disease/conn/978-0-12-809468-6" target="_blank" >https://www.elsevier.com/books/animal-models-for-the-study-of-human-disease/conn/978-0-12-809468-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-809468-6.00007-3" target="_blank" >10.1016/B978-0-12-809468-6.00007-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiovascular Models: Heart Secondarily Affected by Disease (Diabetes Mellitus, Renal Failure, Dysfunctional Sympathetic Innervation)

Popis výsledku v původním jazyce

Impairment, altered function or altered requirements of various organs lead to corresponding changes of cardiovascular system, especially its central organ, the heart. The heart adapts to the altered conditions and requirements by intensive remodeling. The remodeling is usually very complex, including both structural (e.g. hypertrophy, fibrosis) and functional (e.g. electrophysiological, contractile remodeling) changes. The remodeling is initially compensatory and beneficial optimizing the pumping function but gradually it may become detrimental (heart failure, life-threatening arrhythmias). In this chapter we have focused on three experimental models, in which the heart is not targeted primarily, however the primary disease eventually affects the cardiovascular system significantly: diabetes mellitus, renal failure, and dysfunctional autonomic innervation. Rat models of these three conditions are described in detail with special focus on methodological aspects and experimental results obtained in our laboratory.

Název v anglickém jazyce

Cardiovascular Models: Heart Secondarily Affected by Disease (Diabetes Mellitus, Renal Failure, Dysfunctional Sympathetic Innervation)

Popis výsledku anglicky

Impairment, altered function or altered requirements of various organs lead to corresponding changes of cardiovascular system, especially its central organ, the heart. The heart adapts to the altered conditions and requirements by intensive remodeling. The remodeling is usually very complex, including both structural (e.g. hypertrophy, fibrosis) and functional (e.g. electrophysiological, contractile remodeling) changes. The remodeling is initially compensatory and beneficial optimizing the pumping function but gradually it may become detrimental (heart failure, life-threatening arrhythmias). In this chapter we have focused on three experimental models, in which the heart is not targeted primarily, however the primary disease eventually affects the cardiovascular system significantly: diabetes mellitus, renal failure, and dysfunctional autonomic innervation. Rat models of these three conditions are described in detail with special focus on methodological aspects and experimental results obtained in our laboratory.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Animal Models for the Study of Human Disease

ISBN

978-0-12-809468-6

Počet stran výsledku

29

Strana od-do

175-203

Počet stran knihy

1177

Název nakladatele

Elsevier

Místo vydání

London

Kód UT WoS kapitoly

—