Neuronal oscillations and memory retrieval

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10364911" target="_blank" >RIV/00216208:11140/17:10364911 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Neuronal oscillations and memory retrieval

Popis výsledku v původním jazyce

Brain oscillations, reflecting rhythmic excitation and inhibition of neuronal populations, play essential role in coordination of neuronal activity. Study of rhythmic activity in hippocampus revealed its importance for memory processing. However, memory retrieval, the final stage of memory cascade, remains an elusive phenomenon. Analysis of hippocampal network activity during spatial memory retrieval pointed to significance of theta oscillations, the EEG pattern in hippocampus (5-12 Hz) that dominates during periods of active (&quot;online&quot;) processing of information. Recurrent excitation in CA3 subregion of hippocampus keeps the memory network in a stable attractor state. Periodic inhibition during theta oscillations disrupts attractor dynamics and enables memory recall by transition to corresponding network state. The main source of input to hippocampus is entorhinal cortex, whose medial division is dedicated to spatial position representation, while the lateral part is associated with coding for local sensory stimuli. The communication between entorhinal cortex and hippocampus is coordinated by gamma rhythms (25-100 Hz). Which inputs originating in the entorhinal cortex initiate retrieval of memory for spatial context remains unclear. Further studies with simultaneous recording of activity from various hippocampal sub-regions and associated structures could reveal more about dynamics of memory retrieval and their coordination by neuronal oscillations.

Název v anglickém jazyce

Neuronal oscillations and memory retrieval

Popis výsledku anglicky

Brain oscillations, reflecting rhythmic excitation and inhibition of neuronal populations, play essential role in coordination of neuronal activity. Study of rhythmic activity in hippocampus revealed its importance for memory processing. However, memory retrieval, the final stage of memory cascade, remains an elusive phenomenon. Analysis of hippocampal network activity during spatial memory retrieval pointed to significance of theta oscillations, the EEG pattern in hippocampus (5-12 Hz) that dominates during periods of active (&quot;online&quot;) processing of information. Recurrent excitation in CA3 subregion of hippocampus keeps the memory network in a stable attractor state. Periodic inhibition during theta oscillations disrupts attractor dynamics and enables memory recall by transition to corresponding network state. The main source of input to hippocampus is entorhinal cortex, whose medial division is dedicated to spatial position representation, while the lateral part is associated with coding for local sensory stimuli. The communication between entorhinal cortex and hippocampus is coordinated by gamma rhythms (25-100 Hz). Which inputs originating in the entorhinal cortex initiate retrieval of memory for spatial context remains unclear. Further studies with simultaneous recording of activity from various hippocampal sub-regions and associated structures could reveal more about dynamics of memory retrieval and their coordination by neuronal oscillations.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plzeňský lékařský sborník

ISSN

0551-1038

e-ISSN

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Svazek periodika

2017

Číslo periodika v rámci svazku

83

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

19-29

Kód UT WoS článku

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EID výsledku v databázi Scopus

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