Prognostic significance of Fuhrman grade and age for cancer-specific and overall survival in patients with papillary renal cell carcinoma: results of an international multi-institutional study on 2189 patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10365046" target="_blank" >RIV/00216208:11140/17:10365046 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/17:10365046

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00345-017-2078-5" target="_blank" >http://dx.doi.org/10.1007/s00345-017-2078-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00345-017-2078-5" target="_blank" >10.1007/s00345-017-2078-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic significance of Fuhrman grade and age for cancer-specific and overall survival in patients with papillary renal cell carcinoma: results of an international multi-institutional study on 2189 patients

Popis výsledku v původním jazyce

Purpose Because the prognostic impact of the clinical and pathological features on cancer-specific survival (CSS) and overall survival (OS) in patients with papillary renal cell carcinoma (papRCC) is still controversial, we want to assess the impact of clinicopathological features, including Fuhrman grade and age, on survival in surgically treated papRCC patients in a large multi-institutional series. Methods We established a comprehensive multi-institutional database of surgically treated papRCC patients. Histopathological data collected from 2189 patients with papRCC after radical nephrectomy or nephron-sparing surgery were pooled from 18 centres in Europe and North America. OS and CSS probabilities were estimated using the Kaplan- Meier method. Multivariable competing risks analyses were used to assess the impact of Fuhrman grade (FG1-FG4) and age groups (&lt;50 years, 50-75 years, &gt;75 years) on cancerspecific mortality (CSM). Results CSS and OS rates for patients were 89 and 81% at 3 years, 86 and 75% at 5 years and 78 and 41% at 10 years after surgery, respectively. CSM differed significantly between FG 3 (hazard ratio [HR] 4.22, 95% confidence interval [CI] 2.17-8.22; p &lt; 0.001) and FG 4 (HR 8.93, 95% CI 4.25-18.79; p &lt; 0.001) in comparison to FG 1. CSM was significantly worse in patients aged &gt;75 (HR 2.85, 95% CI 2.06-3.95; p &lt; 0.001) compared to &lt;50 years. Conclusions FG is a strong prognostic factor for CSS in papRCC patients. In addition, patients older than 75 have worse CSM than patients younger than 50 years. These findings should be considered for clinical decision making.

Název v anglickém jazyce

Prognostic significance of Fuhrman grade and age for cancer-specific and overall survival in patients with papillary renal cell carcinoma: results of an international multi-institutional study on 2189 patients

Popis výsledku anglicky

Purpose Because the prognostic impact of the clinical and pathological features on cancer-specific survival (CSS) and overall survival (OS) in patients with papillary renal cell carcinoma (papRCC) is still controversial, we want to assess the impact of clinicopathological features, including Fuhrman grade and age, on survival in surgically treated papRCC patients in a large multi-institutional series. Methods We established a comprehensive multi-institutional database of surgically treated papRCC patients. Histopathological data collected from 2189 patients with papRCC after radical nephrectomy or nephron-sparing surgery were pooled from 18 centres in Europe and North America. OS and CSS probabilities were estimated using the Kaplan- Meier method. Multivariable competing risks analyses were used to assess the impact of Fuhrman grade (FG1-FG4) and age groups (&lt;50 years, 50-75 years, &gt;75 years) on cancerspecific mortality (CSM). Results CSS and OS rates for patients were 89 and 81% at 3 years, 86 and 75% at 5 years and 78 and 41% at 10 years after surgery, respectively. CSM differed significantly between FG 3 (hazard ratio [HR] 4.22, 95% confidence interval [CI] 2.17-8.22; p &lt; 0.001) and FG 4 (HR 8.93, 95% CI 4.25-18.79; p &lt; 0.001) in comparison to FG 1. CSM was significantly worse in patients aged &gt;75 (HR 2.85, 95% CI 2.06-3.95; p &lt; 0.001) compared to &lt;50 years. Conclusions FG is a strong prognostic factor for CSS in papRCC patients. In addition, patients older than 75 have worse CSM than patients younger than 50 years. These findings should be considered for clinical decision making.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

World Journal of Urology

ISSN

0724-4983

e-ISSN

—

Svazek periodika

35

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1891-1897

Kód UT WoS článku

000415833400011

EID výsledku v databázi Scopus

2-s2.0-85028020400