Myocardial fibrosis detected by magnetic resonance in systemic sclerosis patients - Relationship with biochemical and echocardiography parameters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10365947" target="_blank" >RIV/00216208:11140/17:10365947 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/17:10365947

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijcard.2017.08.072" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2017.08.072</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2017.08.072" target="_blank" >10.1016/j.ijcard.2017.08.072</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Myocardial fibrosis detected by magnetic resonance in systemic sclerosis patients - Relationship with biochemical and echocardiography parameters

Popis výsledku v původním jazyce

Objectives: Systemic scleroderma (SSc) is a rare connective tissue disease presenting with fibrosis affecting skin and internal organs. Cardiovascular magnetic resonance (CMR) with quantification of extracellular volume (ECV) and T1 mapping might help to detect heart involvement. We aimed to evaluate whether myocardial involvement correlates with functional and laboratory parameters. Methods: Thirty-three asymptomatic SSc patients (29 women, aged 56.6 +/- 12.2 years) and 20 controls (10 women, 53.7 +/- 13.1 years) were examined using CMR, echocardiography, functional pulmonary test and laboratory assessment. Results: SSc patients had higher ECV (27.5 +/- 2.8 vs. 22.8 +/- 1.9%, P &lt; 0.0001) and native T1 values (1258.9 +/- 51.2 vs. 1192.2 +/- 32.6, P &lt; 0.0001) compared to controls. Plasma level of growth differentiation factor 15 (GDF-15) and galectin-3 correlated with ECV (r = 0.35; P = 0.0076 and r = 0.38; P = 0.0081) and native T1 (r = 0.31; P = 0.023 and r = 0.35; P = 0.012). GDF-15 was also negatively correlated with diffusing capacity of the lung for carbon monoxide (r = -0.58; P = 0.0004) and positively correlated with modified Rodnan skin score (r = 0.59; P = 0.0003). Conventional echocardiography parameters were similar in SSc patients and controls. However, the global longitudinal peak systolic strain (GLPS) was lower in SSc patients compared to controls (18.6 +/- 1.6 vs. 21.1 +/- 1.2%; P &lt; 0.0001). GLPS also negatively correlated with native T1 (r = -0.35; P = 0.0097), ECV (r = -0.33; P = 0.014), GDF 15 (r = -0.31; P = 0.022), and galectin-3 (r = -0.37; P = 0.0076). Conclusions: Asymptomatic heart involvement is common in SSc patients and includes focal and diffusemyocardial fibrosis. GDF-15 and galectin-3 were positively correlated with myocardial fibrosis parameters. Future outcome studies must show whether measurement of GDF-15 and galectin-3 in SSC patients might be may be useful in clinical practice.

Název v anglickém jazyce

Myocardial fibrosis detected by magnetic resonance in systemic sclerosis patients - Relationship with biochemical and echocardiography parameters

Popis výsledku anglicky

Objectives: Systemic scleroderma (SSc) is a rare connective tissue disease presenting with fibrosis affecting skin and internal organs. Cardiovascular magnetic resonance (CMR) with quantification of extracellular volume (ECV) and T1 mapping might help to detect heart involvement. We aimed to evaluate whether myocardial involvement correlates with functional and laboratory parameters. Methods: Thirty-three asymptomatic SSc patients (29 women, aged 56.6 +/- 12.2 years) and 20 controls (10 women, 53.7 +/- 13.1 years) were examined using CMR, echocardiography, functional pulmonary test and laboratory assessment. Results: SSc patients had higher ECV (27.5 +/- 2.8 vs. 22.8 +/- 1.9%, P &lt; 0.0001) and native T1 values (1258.9 +/- 51.2 vs. 1192.2 +/- 32.6, P &lt; 0.0001) compared to controls. Plasma level of growth differentiation factor 15 (GDF-15) and galectin-3 correlated with ECV (r = 0.35; P = 0.0076 and r = 0.38; P = 0.0081) and native T1 (r = 0.31; P = 0.023 and r = 0.35; P = 0.012). GDF-15 was also negatively correlated with diffusing capacity of the lung for carbon monoxide (r = -0.58; P = 0.0004) and positively correlated with modified Rodnan skin score (r = 0.59; P = 0.0003). Conventional echocardiography parameters were similar in SSc patients and controls. However, the global longitudinal peak systolic strain (GLPS) was lower in SSc patients compared to controls (18.6 +/- 1.6 vs. 21.1 +/- 1.2%; P &lt; 0.0001). GLPS also negatively correlated with native T1 (r = -0.35; P = 0.0097), ECV (r = -0.33; P = 0.014), GDF 15 (r = -0.31; P = 0.022), and galectin-3 (r = -0.37; P = 0.0076). Conclusions: Asymptomatic heart involvement is common in SSc patients and includes focal and diffusemyocardial fibrosis. GDF-15 and galectin-3 were positively correlated with myocardial fibrosis parameters. Future outcome studies must show whether measurement of GDF-15 and galectin-3 in SSC patients might be may be useful in clinical practice.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

249

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

448-453

Kód UT WoS článku

000414326300097

EID výsledku v databázi Scopus

2-s2.0-85029569634