Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10368899" target="_blank" >RIV/00216208:11140/18:10368899 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10368899

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/cyt.12494/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/cyt.12494/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cyt.12494" target="_blank" >10.1111/cyt.12494</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases

Popis výsledku v původním jazyce

Objective: The aim of this study was to assess the significance of bizarre cells (cellsof squamous origin with a superficial squamous cell-type cytoplasm and charac-terised by multinucleation that produces bizarre nuclear shapes) in liquid- basedcytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-upcorrelation.Methods: Fifteen patients, all with LBC samples containing bizarre cells, were iden-tified in routine ThinPrepâLBC workload. HPV testing was performed in each caseusing residual LBC material. Cytological-histological correlations were reviewed.Results: All 15 LBC samples contained bizarre cells and tested positive for high-riskHPV types. Ten of the 15 cases were identified as atypical squamous cells - cannotexclude an HSIL (ASC-H) with secondary diagnosis of low-grade squamous intraep-ithelial lesion (LSIL), while five cases were identified as high-grade squamous intra-epithelial lesion (HSIL), and a subsequent biopsy was recommended. Additionally,13/15 cases underwent cone biopsy or hysterectomy within 1-11 months, of which10 showed histologically confirmed HSIL end-points. LSIL was present in threecases. Bizarre cells were identified in the HSIL epithelium of five cone biopsies.Conclusions: Identification of bizarre cells in LBC is straightforward and mayfacilitate diagnosis. The cytology of bizarre cells is associated with HSIL in conebiopsies. We recommend assigning LBC samples containing bizarre cells as ASC-Hwith secondary diagnosis of LSIL.

Název v anglickém jazyce

Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases

Popis výsledku anglicky

Objective: The aim of this study was to assess the significance of bizarre cells (cellsof squamous origin with a superficial squamous cell-type cytoplasm and charac-terised by multinucleation that produces bizarre nuclear shapes) in liquid- basedcytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-upcorrelation.Methods: Fifteen patients, all with LBC samples containing bizarre cells, were iden-tified in routine ThinPrepâLBC workload. HPV testing was performed in each caseusing residual LBC material. Cytological-histological correlations were reviewed.Results: All 15 LBC samples contained bizarre cells and tested positive for high-riskHPV types. Ten of the 15 cases were identified as atypical squamous cells - cannotexclude an HSIL (ASC-H) with secondary diagnosis of low-grade squamous intraep-ithelial lesion (LSIL), while five cases were identified as high-grade squamous intra-epithelial lesion (HSIL), and a subsequent biopsy was recommended. Additionally,13/15 cases underwent cone biopsy or hysterectomy within 1-11 months, of which10 showed histologically confirmed HSIL end-points. LSIL was present in threecases. Bizarre cells were identified in the HSIL epithelium of five cone biopsies.Conclusions: Identification of bizarre cells in LBC is straightforward and mayfacilitate diagnosis. The cytology of bizarre cells is associated with HSIL in conebiopsies. We recommend assigning LBC samples containing bizarre cells as ASC-Hwith secondary diagnosis of LSIL.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytopathology

ISSN

0956-5507

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

58-62

Kód UT WoS článku

000419968600008

EID výsledku v databázi Scopus

2-s2.0-85034569268