A more sensitive detection of micrometastases of NSCLC in lymph nodes using the one-step nucleic acid amplification (OSNA) method
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10373784" target="_blank" >RIV/00216208:11140/18:10373784 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00669806:_____/18:10373784
Výsledek na webu
<a href="https://doi.org/10.1002/jso.24826" target="_blank" >https://doi.org/10.1002/jso.24826</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jso.24826" target="_blank" >10.1002/jso.24826</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A more sensitive detection of micrometastases of NSCLC in lymph nodes using the one-step nucleic acid amplification (OSNA) method
Popis výsledku v původním jazyce
Detection of tumor cells in lymph nodes (LNs) removed during the Treatment of pulmonary tumor by radical surgery is limited by the possibilities of standart histopathological methods. The goal of this study was to obtain more accureate pTNM status by a more sensitive detection of micrometastases in LNs. Results: identical results for H&E and OSNA examinations were recorded in 286 groups of LNs (89,4%). In total, positive examinations were recorded in 27 groups of LNs (8,4%) using the OSNA method, which were H&E negative. In 7 groups of LNs (2,2%), the H&E examination was positive, while OSNA method produced negative results. Conclusions: the OSNA examination led to a higher pTNM stage classification in 14 (21,9%) patients. The clinical significance remains the subject of follow-up research.
Název v anglickém jazyce
A more sensitive detection of micrometastases of NSCLC in lymph nodes using the one-step nucleic acid amplification (OSNA) method
Popis výsledku anglicky
Detection of tumor cells in lymph nodes (LNs) removed during the Treatment of pulmonary tumor by radical surgery is limited by the possibilities of standart histopathological methods. The goal of this study was to obtain more accureate pTNM status by a more sensitive detection of micrometastases in LNs. Results: identical results for H&E and OSNA examinations were recorded in 286 groups of LNs (89,4%). In total, positive examinations were recorded in 27 groups of LNs (8,4%) using the OSNA method, which were H&E negative. In 7 groups of LNs (2,2%), the H&E examination was positive, while OSNA method produced negative results. Conclusions: the OSNA examination led to a higher pTNM stage classification in 14 (21,9%) patients. The clinical significance remains the subject of follow-up research.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30212 - Surgery
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Surgical Oncology
ISSN
0022-4790
e-ISSN
—
Svazek periodika
117
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
163-170
Kód UT WoS článku
000426165700008
EID výsledku v databázi Scopus
2-s2.0-85038258405