Dermal fibroblasts-A heterogeneous population with regulatory function in wound healing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10374049" target="_blank" >RIV/00216208:11140/18:10374049 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1359610118300029" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1359610118300029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cytogfr.2018.01.003" target="_blank" >10.1016/j.cytogfr.2018.01.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dermal fibroblasts-A heterogeneous population with regulatory function in wound healing

Popis výsledku v původním jazyce

Dermal fibroblasts, which make up the major cell type in the dermis, have, historically, been considered to be relatively &apos;passive&apos; cells which are responsible for the synthesis and remodeling of extracellular matrix proteins. However, the dermal fibroblast population is composed of heterogeneous and distinct cell types, and it has been established that, under the stress conditions of healing wound environments, dermal fibroblasts participate in the regulation of ongoing inflammation and cell proliferation by secreting a variety of signaling molecules that modulate the functions of immune cells, keratinocyte, endothelial cells and mast cells via both direct cell to cell communication and autocrine and paracrine interactions. This review describes the capacity of dermal fibroblasts to sense and respond to signals from the micro-environment and to communicate with surrounding cells during cutaneous wound healing. The review further emphasizes the, to date, poorly understood roles of heterogeneous dermal fibroblast populations in the wound healing process.

Název v anglickém jazyce

Dermal fibroblasts-A heterogeneous population with regulatory function in wound healing

Popis výsledku anglicky

Dermal fibroblasts, which make up the major cell type in the dermis, have, historically, been considered to be relatively &apos;passive&apos; cells which are responsible for the synthesis and remodeling of extracellular matrix proteins. However, the dermal fibroblast population is composed of heterogeneous and distinct cell types, and it has been established that, under the stress conditions of healing wound environments, dermal fibroblasts participate in the regulation of ongoing inflammation and cell proliferation by secreting a variety of signaling molecules that modulate the functions of immune cells, keratinocyte, endothelial cells and mast cells via both direct cell to cell communication and autocrine and paracrine interactions. This review describes the capacity of dermal fibroblasts to sense and respond to signals from the micro-environment and to communicate with surrounding cells during cutaneous wound healing. The review further emphasizes the, to date, poorly understood roles of heterogeneous dermal fibroblast populations in the wound healing process.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytokine and Growth Factor Reviews

ISSN

1359-6101

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

137-150

Kód UT WoS článku

000430185700012

EID výsledku v databázi Scopus

2-s2.0-85041126936