Follicular fluid levels of anti-Mullerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10375960" target="_blank" >RIV/00216208:11140/18:10375960 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10375960

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/19396368.2018.1450906" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/19396368.2018.1450906</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/19396368.2018.1450906" target="_blank" >10.1080/19396368.2018.1450906</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Follicular fluid levels of anti-Mullerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders

Popis výsledku v původním jazyce

Anti-Mullerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason. IGF1 was the only biomarker with significantly lower levels throughout the entire group with fertility disorders. We did not identify any statistically significant differences for AMH and leptin. Regarding subgroups, significant differences were only observed in the group of anovulatory women. AMH and leptin showed higher levels while IGF1 showed lower levels. In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology.Abbreviations: AMH: anti-Mullerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome

Název v anglickém jazyce

Follicular fluid levels of anti-Mullerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders

Popis výsledku anglicky

Anti-Mullerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason. IGF1 was the only biomarker with significantly lower levels throughout the entire group with fertility disorders. We did not identify any statistically significant differences for AMH and leptin. Regarding subgroups, significant differences were only observed in the group of anovulatory women. AMH and leptin showed higher levels while IGF1 showed lower levels. In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology.Abbreviations: AMH: anti-Mullerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Systems biology in reproductive medicine

ISSN

1939-6368

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

220-223

Kód UT WoS článku

000432658800009

EID výsledku v databázi Scopus

2-s2.0-85044516410