Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10376629" target="_blank" >RIV/00216208:11140/18:10376629 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10376629

Výsledek na webu

<a href="https://insights.ovid.com/pubmed?pmid=29112060" target="_blank" >https://insights.ovid.com/pubmed?pmid=29112060</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/QAD.0000000000001684" target="_blank" >10.1097/QAD.0000000000001684</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?

Popis výsledku v původním jazyce

Objective:The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown.Method:EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4(+) cell count 350/l, viral load 10000 copies/ml), low risk (CD4(+) cell count 500 cells/l, viral load &lt;50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events.Results:A total of 16839 persons were included with 136688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-to-three-fold increase in older persons (P=0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-to-four-fold difference in all other regions (P=0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P&lt;0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P=0.57, 0.060 and 0.090, respectively, interaction).Conclusion:Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care.

Název v anglickém jazyce

Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?

Popis výsledku anglicky

Objective:The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown.Method:EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4(+) cell count 350/l, viral load 10000 copies/ml), low risk (CD4(+) cell count 500 cells/l, viral load &lt;50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events.Results:A total of 16839 persons were included with 136688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-to-three-fold increase in older persons (P=0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-to-four-fold difference in all other regions (P=0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P&lt;0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P=0.57, 0.060 and 0.090, respectively, interaction).Conclusion:Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AIDS

ISSN

0269-9370

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

205-215

Kód UT WoS článku

000418864000008

EID výsledku v databázi Scopus

2-s2.0-85039718151