Pathological human astroglia in Alzheimer's disease: opening new horizons with stem cell technology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10376867" target="_blank" >RIV/00216208:11140/18:10376867 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.futuremedicine.com/doi/pdf/10.2217/fnl-2017-0029" target="_blank" >https://www.futuremedicine.com/doi/pdf/10.2217/fnl-2017-0029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/fnl-2017-0029" target="_blank" >10.2217/fnl-2017-0029</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pathological human astroglia in Alzheimer's disease: opening new horizons with stem cell technology

Popis výsledku v původním jazyce

Pathological remodeling, degeneration and reactivity of astrocytes are fundamental astrogliopathies contributing to all neurological diseases. In neurodegenerative disorders (including Alzheimer&apos;s disease [AD]) astroglia undergo complex changes that range from atrophy with loss of function to accumulation of reactive cells around disease-specific lesions (senile plaques in the case of AD). The cellular pathology of astroglia in the context of human AD remains enigmatic; mainly because of the severe limitations of animal models, which, although reproducing some pathological features of the disease, do not mimic its progression in full. Human-induced pluripotent stem cells technology creates a novel and potentially revolutionizing platform for studying fundamental mechanisms of the disease and for screening to identify new therapeutic compounds.

Název v anglickém jazyce

Pathological human astroglia in Alzheimer's disease: opening new horizons with stem cell technology

Popis výsledku anglicky

Pathological remodeling, degeneration and reactivity of astrocytes are fundamental astrogliopathies contributing to all neurological diseases. In neurodegenerative disorders (including Alzheimer&apos;s disease [AD]) astroglia undergo complex changes that range from atrophy with loss of function to accumulation of reactive cells around disease-specific lesions (senile plaques in the case of AD). The cellular pathology of astroglia in the context of human AD remains enigmatic; mainly because of the severe limitations of animal models, which, although reproducing some pathological features of the disease, do not mimic its progression in full. Human-induced pluripotent stem cells technology creates a novel and potentially revolutionizing platform for studying fundamental mechanisms of the disease and for screening to identify new therapeutic compounds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Future Neurology

ISSN

1479-6708

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

87-100

Kód UT WoS článku

000433465700006

EID výsledku v databázi Scopus

2-s2.0-85047765344