Risk factors for failure of continuous positive airway pressure treatment in patients with ob- structive sleep apnoea

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10377149" target="_blank" >RIV/00216208:11140/18:10377149 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10377149

Výsledek na webu

<a href="http://biomed.papers.upol.cz/artkey/bio-201802-0010_risk_factors_for_failure_of_continuous_positive_airway_pressure_treatment_in_patients_with_ostructive_sleep_apn.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201802-0010_risk_factors_for_failure_of_continuous_positive_airway_pressure_treatment_in_patients_with_ostructive_sleep_apn.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2017.056" target="_blank" >10.5507/bp.2017.056</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Risk factors for failure of continuous positive airway pressure treatment in patients with ob- structive sleep apnoea

Popis výsledku v původním jazyce

Obstructive sleep apnoea is a potentially serious sleep disorder associated with the risk of cardiovascular disease. It is treated with continuous airway pressure (CPAP) but this is not always successful. Unsuccessful cases should be treated by bilevel positive airway pressure (BiPAP). The aim of this study was to determine whether common respiratory parameters and/or body mass index (BMI) can be used to predict the probability CPAP failure and hence start such pa- tients on BiPAP from the outset. A sample of patients treated by CPAP for OSAS was evaluated a retrospective cohort study. The data measured in sleep monitoring of the successfully treated group and of the group whe- re CPAP had failed were compared. Subsequently, the predictive abilities of BMI, Apnoea Index (AI), Apnoea-Hypopnea Index (AHI), percentage of sleep time in less than 90% oxygen saturation (T90), average oxygen saturation over the duration of sleep (SaO2) and average desaturation per hour of sleep (ODI) were assessed with respect to CPAP failure, both individually and in combina- tion. A sample of 479 patients was included in the study. All of the recorded variables except AI were significantly associated with failure of CPAP and their ability to predict the failure ranged from poor to moderate. Since there was significant correlation among all the variables measured a two-variable prediction model combining T90 and BMI produced no significant improvement in the quality of CPAP failure prediction. BMI was a significant predictor of CPAP failure although it was slightly less pre- dictive than T90. The set of monitored variables included in our study does not allow for CPAP failu- re to be predicted with clinically relevant reliability.

Název v anglickém jazyce

Risk factors for failure of continuous positive airway pressure treatment in patients with ob- structive sleep apnoea

Popis výsledku anglicky

Obstructive sleep apnoea is a potentially serious sleep disorder associated with the risk of cardiovascular disease. It is treated with continuous airway pressure (CPAP) but this is not always successful. Unsuccessful cases should be treated by bilevel positive airway pressure (BiPAP). The aim of this study was to determine whether common respiratory parameters and/or body mass index (BMI) can be used to predict the probability CPAP failure and hence start such pa- tients on BiPAP from the outset. A sample of patients treated by CPAP for OSAS was evaluated a retrospective cohort study. The data measured in sleep monitoring of the successfully treated group and of the group whe- re CPAP had failed were compared. Subsequently, the predictive abilities of BMI, Apnoea Index (AI), Apnoea-Hypopnea Index (AHI), percentage of sleep time in less than 90% oxygen saturation (T90), average oxygen saturation over the duration of sleep (SaO2) and average desaturation per hour of sleep (ODI) were assessed with respect to CPAP failure, both individually and in combina- tion. A sample of 479 patients was included in the study. All of the recorded variables except AI were significantly associated with failure of CPAP and their ability to predict the failure ranged from poor to moderate. Since there was significant correlation among all the variables measured a two-variable prediction model combining T90 and BMI produced no significant improvement in the quality of CPAP failure prediction. BMI was a significant predictor of CPAP failure although it was slightly less pre- dictive than T90. The set of monitored variables included in our study does not allow for CPAP failu- re to be predicted with clinically relevant reliability.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30206 - Otorhinolaryngology

Projekt

<a href="/cs/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

162

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

134-138

Kód UT WoS článku

000436347500010

EID výsledku v databázi Scopus

2-s2.0-85049083212