Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10381187" target="_blank" >RIV/00216208:11140/18:10381187 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10381187

Výsledek na webu

<a href="https://doi.org/10.1136/heartjnl-2017-312569" target="_blank" >https://doi.org/10.1136/heartjnl-2017-312569</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/heartjnl-2017-312569" target="_blank" >10.1136/heartjnl-2017-312569</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes

Popis výsledku v původním jazyce

Objectives Determinants of atrial fibrillation (AF) patterns and of progression of earlier forms to permanent AF, and their relationship with outcome are still poorly understood. Methods We examined AF patterns (paroxysmal, persistent and permanent), rate and predictors of AF progression, and outcomes in the PREFER (PREvention oF thromboembolic events-European Registry) in AF. The primary analysis was performed in the PREFER in AF prolongation dataset (n=3223patients with AF with a complete 1-year follow-up, mean age 729 years, 40% women). Sensitivity analyses were performed using the PREFER in the AF study (n=6390 patients). Results AF progressed to more persistent types in 506 patients (17%). Permanent AF was associated with development of heart failure at 1year (OR 1.80, 95% CI 1.06 to 3.07, p=0.03) compared with paroxysmal AF, which was confirmed in the entire cohort. In multivariable-adjusted models, sinus rhythm at baseline, AF duration, cardioversion, hyperthyroidism, valvular heart disease, diabetes mellitus and heart failure were predictors of AF progression (area under the receiver operating characteristic curve 0.60, 95%CI 0.57 to 0.63). Results were similar when we restricted analyses to patients with AF duration &lt;1year. AF progression showed an association with coronary events over 1year (OR 2.27, 95%CI 1.22 to 4.19, p=0.0074). Conclusions Permanent AF at baseline was associated with incident heart failure. A substantial proportion of well-managed patients with AF showed AF progression over 1year. AF progression itself was not strongly related to outcome and may indicate the need to refine the current classification of AF types to enhance clinical utility.

Název v anglickém jazyce

Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes

Popis výsledku anglicky

Objectives Determinants of atrial fibrillation (AF) patterns and of progression of earlier forms to permanent AF, and their relationship with outcome are still poorly understood. Methods We examined AF patterns (paroxysmal, persistent and permanent), rate and predictors of AF progression, and outcomes in the PREFER (PREvention oF thromboembolic events-European Registry) in AF. The primary analysis was performed in the PREFER in AF prolongation dataset (n=3223patients with AF with a complete 1-year follow-up, mean age 729 years, 40% women). Sensitivity analyses were performed using the PREFER in the AF study (n=6390 patients). Results AF progressed to more persistent types in 506 patients (17%). Permanent AF was associated with development of heart failure at 1year (OR 1.80, 95% CI 1.06 to 3.07, p=0.03) compared with paroxysmal AF, which was confirmed in the entire cohort. In multivariable-adjusted models, sinus rhythm at baseline, AF duration, cardioversion, hyperthyroidism, valvular heart disease, diabetes mellitus and heart failure were predictors of AF progression (area under the receiver operating characteristic curve 0.60, 95%CI 0.57 to 0.63). Results were similar when we restricted analyses to patients with AF duration &lt;1year. AF progression showed an association with coronary events over 1year (OR 2.27, 95%CI 1.22 to 4.19, p=0.0074). Conclusions Permanent AF at baseline was associated with incident heart failure. A substantial proportion of well-managed patients with AF showed AF progression over 1year. AF progression itself was not strongly related to outcome and may indicate the need to refine the current classification of AF types to enhance clinical utility.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Heart

ISSN

1355-6037

e-ISSN

—

Svazek periodika

104

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

1608-1614

Kód UT WoS článku

000446083900012

EID výsledku v databázi Scopus

2-s2.0-85049139655