Endothelial dysfunction in children and young adults: A combined diagnostic approach of plethysmographic and biochemical markers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10384952" target="_blank" >RIV/00216208:11140/18:10384952 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10384952

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Endothelial dysfunction in children and young adults: A combined diagnostic approach of plethysmographic and biochemical markers

Popis výsledku v původním jazyce

We provide current, normative data on a new examination method of endothelial dysfunction (ED) in childhood. The reversibility of ED is anattractive primary target in the effort to decrease cardiovascular risk in pediatric patients and to optimize therapeutic strategies. Thus, early detection of ED may have therapeutic and prognostic implications. Novel non-invasive diagnostic tools ensuring the capture of ED are needed. One of them is the combined diagnostic approach of plethysmographic and laboratory methods that our current research concentrates on. The objective of our prospective study was to evaluate endothelial dysfunction especially in children with chronic diseases using a combination of plethysmographic reactive hyperemia index (RHI) and specific biomarkers - plasma concentrations of assymetric dimethylarginine (ADMA), high-sensitive C-reactive protein (hsCRP), E-selectine and vasoadhesive molecules (VCAM) in comparison with the healthy controls. RHI was further correlated with anthropometric and biochemical parameters. Significantly decreased RHI with elevated plasma concentrations of biochemical markers implies a possible association with premature ED in patients with chronic diseases. The combined diagnostic approach seems to be a valuable tool for more accurate detection of ED and preventive cardiovascular management in these patients [1]. (C) 2018 Nova Science Publishers, Inc. All rights reserved.

Název v anglickém jazyce

Endothelial dysfunction in children and young adults: A combined diagnostic approach of plethysmographic and biochemical markers

Popis výsledku anglicky

We provide current, normative data on a new examination method of endothelial dysfunction (ED) in childhood. The reversibility of ED is anattractive primary target in the effort to decrease cardiovascular risk in pediatric patients and to optimize therapeutic strategies. Thus, early detection of ED may have therapeutic and prognostic implications. Novel non-invasive diagnostic tools ensuring the capture of ED are needed. One of them is the combined diagnostic approach of plethysmographic and laboratory methods that our current research concentrates on. The objective of our prospective study was to evaluate endothelial dysfunction especially in children with chronic diseases using a combination of plethysmographic reactive hyperemia index (RHI) and specific biomarkers - plasma concentrations of assymetric dimethylarginine (ADMA), high-sensitive C-reactive protein (hsCRP), E-selectine and vasoadhesive molecules (VCAM) in comparison with the healthy controls. RHI was further correlated with anthropometric and biochemical parameters. Significantly decreased RHI with elevated plasma concentrations of biochemical markers implies a possible association with premature ED in patients with chronic diseases. The combined diagnostic approach seems to be a valuable tool for more accurate detection of ED and preventive cardiovascular management in these patients [1]. (C) 2018 Nova Science Publishers, Inc. All rights reserved.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30209 - Paediatrics

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Health and Disease

ISBN

978-1-5361-3951-8

Počet stran výsledku

14

Strana od-do

189-202

Počet stran knihy

273

Název nakladatele

Nova Science Publishers, Inc.

Místo vydání

New York

Kód UT WoS kapitoly

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