Low-dose High-resolution F-18-FDG-PET/CT Using Time-of-flight and Point-spread Function Reconstructions: A Role in the Detection of Breast Carcinoma Axillary Lymph Node Metastases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10386446" target="_blank" >RIV/00216208:11140/18:10386446 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10386446

Výsledek na webu

<a href="https://doi.org/10.21873/anticanres.12706" target="_blank" >https://doi.org/10.21873/anticanres.12706</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.12706" target="_blank" >10.21873/anticanres.12706</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low-dose High-resolution F-18-FDG-PET/CT Using Time-of-flight and Point-spread Function Reconstructions: A Role in the Detection of Breast Carcinoma Axillary Lymph Node Metastases

Popis výsledku v původním jazyce

Aim: to evaluate the performance of N-staging assessment in clinically-proven T1 breast carcinoma by high-resolution F-18-fluorodeoxyglucose-positron-emission tomography/computed tomography (F-18-FDG-PETICT) using time-of-flight with point-spread function reconstruction. Patients and Methods: In 30 women with clinically proven T1 breast carcinoma, imaging before surgery was performed using F-18-FDG-PETICT. The results of PET/CT in detection of lymph node metastases were compared with those obtained after pathological investigation of axillary biopsy. A four-ring PET subsystem with image reconstruction using time-of-flight and point-spread function was used with the radiopharmaceutical dose reduction to 2.5 MBq/kg. Results: Axillary lymph node metastasis was confirmed by histology in 13 patients, but metastasis was suspected based on PET/CT in 12 of those patients, the absence of metastasis was surgically confirmed in 17 women, 15 of which were suspected based on PET/CT. The sensitivity for detection of axillary lymph node metastasis was 93.3%, with a specificity of 88.2% in the whole patient cohort. Additionally, distant metastatic spread was found in 13.3% of patients. Conclusion: The reconstruction of PET images with time-of-flight and point-spread function enabled the improvement of diagnostic performance in N-staging of breast carcinoma, even when the dose of radiopharmaceutical was reduced to 2.5 MBq/kg

Název v anglickém jazyce

Low-dose High-resolution F-18-FDG-PET/CT Using Time-of-flight and Point-spread Function Reconstructions: A Role in the Detection of Breast Carcinoma Axillary Lymph Node Metastases

Popis výsledku anglicky

Aim: to evaluate the performance of N-staging assessment in clinically-proven T1 breast carcinoma by high-resolution F-18-fluorodeoxyglucose-positron-emission tomography/computed tomography (F-18-FDG-PETICT) using time-of-flight with point-spread function reconstruction. Patients and Methods: In 30 women with clinically proven T1 breast carcinoma, imaging before surgery was performed using F-18-FDG-PETICT. The results of PET/CT in detection of lymph node metastases were compared with those obtained after pathological investigation of axillary biopsy. A four-ring PET subsystem with image reconstruction using time-of-flight and point-spread function was used with the radiopharmaceutical dose reduction to 2.5 MBq/kg. Results: Axillary lymph node metastasis was confirmed by histology in 13 patients, but metastasis was suspected based on PET/CT in 12 of those patients, the absence of metastasis was surgically confirmed in 17 women, 15 of which were suspected based on PET/CT. The sensitivity for detection of axillary lymph node metastasis was 93.3%, with a specificity of 88.2% in the whole patient cohort. Additionally, distant metastatic spread was found in 13.3% of patients. Conclusion: The reconstruction of PET images with time-of-flight and point-spread function enabled the improvement of diagnostic performance in N-staging of breast carcinoma, even when the dose of radiopharmaceutical was reduced to 2.5 MBq/kg

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Svazek periodika

38

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

4

Strana od-do

4145-4148

Kód UT WoS článku

000449943500045

EID výsledku v databázi Scopus

2-s2.0-85049795130