"Fat-rich" (Spindle Cell-poor) Variants of Atypical Spindle Cell Lipomatous Tumors Show Similar Morphologic, Immunohistochemical and Molecular Features as "Dysplastic Lipomas" Are They Related Lesions?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10395314" target="_blank" >RIV/00216208:11140/19:10395314 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ylM74Oj1rS" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ylM74Oj1rS</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PAS.0000000000001184" target="_blank" >10.1097/PAS.0000000000001184</a>

Jazyk výsledku

angličtina

Název v původním jazyce

"Fat-rich" (Spindle Cell-poor) Variants of Atypical Spindle Cell Lipomatous Tumors Show Similar Morphologic, Immunohistochemical and Molecular Features as "Dysplastic Lipomas" Are They Related Lesions?

Popis výsledku v původním jazyce

We appreciated the interest of Dr Creytens et al in our recent publication on dysplastic lipoma.1 This tumor has: (1) a very strong male predominance, (2) a predilection for the posterior neck, upper back and shoulder regions, (3) multifocality in TILDE OPERATOR+D9119% of patients, (4) a rare association with retinoblastoma, and (5) mildly increased risk (currently estimated at around 10%) for local recurrence with simple excision, as compared with a conventional lipoma. To date, all examples have been subcutaneous, though some examples have occurred in locations were tissue planes are somewhat ambiguous (eg, the lateral/anterior neck and groin regions). The key histologic features are: (1) notable adipocytic size variation, (2) patchy (typically single cell) fat necrosis, and (3) focal adipocytic nuclear atypia. The atypical adipocytes may be mononucleated or multinucleated. The atypia is generally mild and can be quite subtle, but in some instances, it is more pronounced and similar to that seen in a conventional atypical lipomatous tumor. Immunohistochemical expression for p53 is always present, but it is limited to a subpopulation of the adipocytes, typically those with the greatest atypia. MDM2 immunoexpression can be present, but it is almost invariably less prominent than the p53 immunoexpression, and FISH analysis for MDM2 gene amplification is always negative.

Název v anglickém jazyce

"Fat-rich" (Spindle Cell-poor) Variants of Atypical Spindle Cell Lipomatous Tumors Show Similar Morphologic, Immunohistochemical and Molecular Features as "Dysplastic Lipomas" Are They Related Lesions?

Popis výsledku anglicky

We appreciated the interest of Dr Creytens et al in our recent publication on dysplastic lipoma.1 This tumor has: (1) a very strong male predominance, (2) a predilection for the posterior neck, upper back and shoulder regions, (3) multifocality in TILDE OPERATOR+D9119% of patients, (4) a rare association with retinoblastoma, and (5) mildly increased risk (currently estimated at around 10%) for local recurrence with simple excision, as compared with a conventional lipoma. To date, all examples have been subcutaneous, though some examples have occurred in locations were tissue planes are somewhat ambiguous (eg, the lateral/anterior neck and groin regions). The key histologic features are: (1) notable adipocytic size variation, (2) patchy (typically single cell) fat necrosis, and (3) focal adipocytic nuclear atypia. The atypical adipocytes may be mononucleated or multinucleated. The atypia is generally mild and can be quite subtle, but in some instances, it is more pronounced and similar to that seen in a conventional atypical lipomatous tumor. Immunohistochemical expression for p53 is always present, but it is limited to a subpopulation of the adipocytes, typically those with the greatest atypia. MDM2 immunoexpression can be present, but it is almost invariably less prominent than the p53 immunoexpression, and FISH analysis for MDM2 gene amplification is always negative.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

<a href="/cs/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The American Journal of Surgical Pathology

ISSN

0147-5185

e-ISSN

—

Svazek periodika

43

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

2

Strana od-do

289-290

Kód UT WoS článku

000458401800018

EID výsledku v databázi Scopus

2-s2.0-85056725042