Lack of deletion of 1p36 in 8 cases of primary adenoid cystic carcinoma of the skin
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10399084" target="_blank" >RIV/00216208:11140/19:10399084 - isvavai.cz</a>
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EpBfhdZC1_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EpBfhdZC1_</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/DAD.0000000000001294" target="_blank" >10.1097/DAD.0000000000001294</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Lack of deletion of 1p36 in 8 cases of primary adenoid cystic carcinoma of the skin
Popis výsledku v původním jazyce
In our previous study, we have demonstrated that primary cutaneous adenoid cystic carcinoma (ACC) manifests genetic changes similar to its salivary gland homologue, including alterations in the MYB and MYBL1 genes.1 Deletion of the 1p36 locus has been shown in salivary gland ACC (range of detection: 0%-44%),2-4 in which this alteration has been found to be associated with reduced overall survival, higher tumor stage, lower recurrence-free interval, lower recurrence-free survival, solid histology, and the absence of MYBL1 break.4,5 As this technique has now become available for us, we investigated our previously published cohort of 10 patients with primary cutaneous ACC.1 FISH for 1p36 was performed, as described elsewhere.5 The analysis was successful in 8 of the 10 cutaneous neoplasms. All the cases, including 2 patients who died of metastatic disease, proved negative. It seems that the deletion of 1p36 is not a feature of cutaneous ACC, but further studies on larger series are needed to confirm this assumption.
Název v anglickém jazyce
Lack of deletion of 1p36 in 8 cases of primary adenoid cystic carcinoma of the skin
Popis výsledku anglicky
In our previous study, we have demonstrated that primary cutaneous adenoid cystic carcinoma (ACC) manifests genetic changes similar to its salivary gland homologue, including alterations in the MYB and MYBL1 genes.1 Deletion of the 1p36 locus has been shown in salivary gland ACC (range of detection: 0%-44%),2-4 in which this alteration has been found to be associated with reduced overall survival, higher tumor stage, lower recurrence-free interval, lower recurrence-free survival, solid histology, and the absence of MYBL1 break.4,5 As this technique has now become available for us, we investigated our previously published cohort of 10 patients with primary cutaneous ACC.1 FISH for 1p36 was performed, as described elsewhere.5 The analysis was successful in 8 of the 10 cutaneous neoplasms. All the cases, including 2 patients who died of metastatic disease, proved negative. It seems that the deletion of 1p36 is not a feature of cutaneous ACC, but further studies on larger series are needed to confirm this assumption.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30109 - Pathology
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
The American Journal of Dermatopathology
ISSN
0193-1091
e-ISSN
—
Svazek periodika
41
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
2
Strana od-do
781-782
Kód UT WoS článku
000509675000021
EID výsledku v databázi Scopus
2-s2.0-85072745591