Heparin-induced thrombocytopenia treated with fondaparinux: single centre experience

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10403517" target="_blank" >RIV/00216208:11140/20:10403517 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/20:10403517 RIV/00179906:_____/20:10403517 RIV/00669806:_____/20:10403517

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Li0lVxyNU9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Li0lVxyNU9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S0392-9590.19.04247-0" target="_blank" >10.23736/S0392-9590.19.04247-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Heparin-induced thrombocytopenia treated with fondaparinux: single centre experience

Popis výsledku v původním jazyce

BACKGROUND:Heparin-induced thrombocytopenia (HIT) is the most frequent drug- induced, immune-mediated thrombocytopenia. It is associated with significant morbidity and mortality. Anticoagulation with heparin must be stopped immediately and replaced by some suggested alternative - lepirudin, danaparoid or argatroban. Fondaparinux has been also successfully used in HIT.METHODS:We present a cohort of 10 patients diagnosed with HIT and treated in a university hospital in a period of four years. Diagnosis was based on Keeling s scoring system, screening imunologic test for HIT (STic EXPERT(R) HIT) and sandwich ELISA (detection of IgG/ heparin-PF4 antibodies). While other alternative anticoagulants are not readily available in our hospital, we used fondaparinux in all cases.RESULTS:From 2014 to 2018, eight males and two females (mean age 67 years, range 46-86 years) were diagnosed with HIT in our hospital. This complication developed in 9 cases after low-molecular-weight heparin and in one after heparin flushes in hemodialysis. A drop in platelet count developed in all patients, thrombotic complications in 7 and skin necrosis in 2 cases. Fondaparinux was used in all patients, including two cases with severe renal impairment, the dose was chosen individually. We observed complete platelet recovery in all cases. One patient died because of advanced malignancy, others did not have any complication. In 6 cases we switched to oral anticoagulation after platelet recovery.CONCLUSIONS:In our group of 10 HIT patients fondaparinux was shown to be both safe and effective, even in those with severe renal impairment. Additional studies are warranted to confirm this observation.

Název v anglickém jazyce

Heparin-induced thrombocytopenia treated with fondaparinux: single centre experience

Popis výsledku anglicky

BACKGROUND:Heparin-induced thrombocytopenia (HIT) is the most frequent drug- induced, immune-mediated thrombocytopenia. It is associated with significant morbidity and mortality. Anticoagulation with heparin must be stopped immediately and replaced by some suggested alternative - lepirudin, danaparoid or argatroban. Fondaparinux has been also successfully used in HIT.METHODS:We present a cohort of 10 patients diagnosed with HIT and treated in a university hospital in a period of four years. Diagnosis was based on Keeling s scoring system, screening imunologic test for HIT (STic EXPERT(R) HIT) and sandwich ELISA (detection of IgG/ heparin-PF4 antibodies). While other alternative anticoagulants are not readily available in our hospital, we used fondaparinux in all cases.RESULTS:From 2014 to 2018, eight males and two females (mean age 67 years, range 46-86 years) were diagnosed with HIT in our hospital. This complication developed in 9 cases after low-molecular-weight heparin and in one after heparin flushes in hemodialysis. A drop in platelet count developed in all patients, thrombotic complications in 7 and skin necrosis in 2 cases. Fondaparinux was used in all patients, including two cases with severe renal impairment, the dose was chosen individually. We observed complete platelet recovery in all cases. One patient died because of advanced malignancy, others did not have any complication. In 6 cases we switched to oral anticoagulation after platelet recovery.CONCLUSIONS:In our group of 10 HIT patients fondaparinux was shown to be both safe and effective, even in those with severe renal impairment. Additional studies are warranted to confirm this observation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Angiology

ISSN

0392-9590

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

6

Strana od-do

76-81

Kód UT WoS článku

000550122800009

EID výsledku v databázi Scopus

2-s2.0-85081094215