Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10404748" target="_blank" >RIV/00216208:11140/20:10404748 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00072877 RIV/00216224:14110/20:00118068

Výsledek na webu

<a href="http://dx.doi.org/10.5772/intechopen.88142" target="_blank" >http://dx.doi.org/10.5772/intechopen.88142</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/intechopen.88142" target="_blank" >10.5772/intechopen.88142</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Popis výsledku v původním jazyce

Endocrine disruptors (EDs) are chemical substances that affect physiological processes in the body via hormonal regulation. They are often detected in food, plastic water bottles, cosmetics, and many other daily need items. Thereafter, EDs are detected in many bodily fluids, pointing out the real exposure to even very low doses. Permanent and long-term utilization of EDs has harmful effects on male reproductive health mainly due to interference with sex hormone synthesis and mechanism of action. However, with decreasing dosage of EDs, the possibilities of unpredictable modes of action arise. In addition to various molecular actions of individual EDs, the interference of individual ones represents another dimension of the ED issue. This review provides an overview of the EDs and their possible impact on reproductive health in males, with focus on sperm quality with the mighty potential of epigenetic transmission to further generations. The &quot;posttranslational&quot; effect of EDs in really low doses in real exposure routes is stigmatized in this review, being strongly considered as creeping molecular action of individual EDs as well as amplifications of their copresence in the environment.

Název v anglickém jazyce

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Popis výsledku anglicky

Endocrine disruptors (EDs) are chemical substances that affect physiological processes in the body via hormonal regulation. They are often detected in food, plastic water bottles, cosmetics, and many other daily need items. Thereafter, EDs are detected in many bodily fluids, pointing out the real exposure to even very low doses. Permanent and long-term utilization of EDs has harmful effects on male reproductive health mainly due to interference with sex hormone synthesis and mechanism of action. However, with decreasing dosage of EDs, the possibilities of unpredictable modes of action arise. In addition to various molecular actions of individual EDs, the interference of individual ones represents another dimension of the ED issue. This review provides an overview of the EDs and their possible impact on reproductive health in males, with focus on sperm quality with the mighty potential of epigenetic transmission to further generations. The &quot;posttranslational&quot; effect of EDs in really low doses in real exposure routes is stigmatized in this review, being strongly considered as creeping molecular action of individual EDs as well as amplifications of their copresence in the environment.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Male Reproductive Health

ISBN

978-1-78985-648-4

Počet stran výsledku

21

Strana od-do

1-21

Počet stran knihy

202

Název nakladatele

IntechOpen

Místo vydání

London

Kód UT WoS kapitoly

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