Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10411765" target="_blank" >RIV/00216208:11140/20:10411765 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064190:_____/20:N0000016 RIV/00023001:_____/20:00080484 RIV/00216208:11110/20:10411765

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7hWTBmJgEt" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7hWTBmJgEt</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jch.13847" target="_blank" >10.1111/jch.13847</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?

Popis výsledku v původním jazyce

Our aim was to determine the serum uric acid (SUA) levels associated with an increased risk of cardiovascular (CV) and all-cause death in the general adult population. We analyzed data obtained in two independent cross-sectional surveys performed in the Czech Republic in 2006-09 and 2015-18, involving 1% population random samples in nine districts, aged 25-64 years, stratified by age and gender. Ten-year mortality data were obtained in a cohort with examination in 2006-09. Final analyses included 3542 individuals (48.2% men) examined in 2006-09, and 2304 (47.4% men) examined in 2015-18. From a cohort examined in 2006-09, 122 men and 60 women were reported dead (33% and 27% from CV disease). In men, there was no association of baseline SUA levels with baseline SCORE category or 10-year mortality rates. In women, each 10 mu mol/L increase in baseline SUA levels was associated with an increase in baseline SCORE category (P &lt; .001). Receiver operating characteristic curve analyses in women identified the baseline SUA cutoff values discriminating: 1. between low/intermediate and high/very high SCORE categories (309 mu mol/L), 2. CV mortality (325 mu mol/L), and 3. all-cause mortality (298 mu mol/L). After adjusting for confounders including SCORE, Cox regression analysis confirmed that the baseline SUA cutoffs of 309 mu mol/L and 325 mu mol/L were associated with 4-times (P = .010) and 6-times (P = .036) greater risk of CV mortality, whereas the cutoff of 298 mu mol/L was associated with 87% greater risk of all-cause mortality (P = .025). In conclusion, the SUA cutoff value of 309 mu mol/L identified women at high/very high SCORE category and was associated with 4-times greater risk of observed CV mortality over 10 years.

Název v anglickém jazyce

Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?

Popis výsledku anglicky

Our aim was to determine the serum uric acid (SUA) levels associated with an increased risk of cardiovascular (CV) and all-cause death in the general adult population. We analyzed data obtained in two independent cross-sectional surveys performed in the Czech Republic in 2006-09 and 2015-18, involving 1% population random samples in nine districts, aged 25-64 years, stratified by age and gender. Ten-year mortality data were obtained in a cohort with examination in 2006-09. Final analyses included 3542 individuals (48.2% men) examined in 2006-09, and 2304 (47.4% men) examined in 2015-18. From a cohort examined in 2006-09, 122 men and 60 women were reported dead (33% and 27% from CV disease). In men, there was no association of baseline SUA levels with baseline SCORE category or 10-year mortality rates. In women, each 10 mu mol/L increase in baseline SUA levels was associated with an increase in baseline SCORE category (P &lt; .001). Receiver operating characteristic curve analyses in women identified the baseline SUA cutoff values discriminating: 1. between low/intermediate and high/very high SCORE categories (309 mu mol/L), 2. CV mortality (325 mu mol/L), and 3. all-cause mortality (298 mu mol/L). After adjusting for confounders including SCORE, Cox regression analysis confirmed that the baseline SUA cutoffs of 309 mu mol/L and 325 mu mol/L were associated with 4-times (P = .010) and 6-times (P = .036) greater risk of CV mortality, whereas the cutoff of 298 mu mol/L was associated with 87% greater risk of all-cause mortality (P = .025). In conclusion, the SUA cutoff value of 309 mu mol/L identified women at high/very high SCORE category and was associated with 4-times greater risk of observed CV mortality over 10 years.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NV15-27109A" target="_blank" >NV15-27109A: Dlouhodobé trendy hlavních kardiovaskulárních rizikových faktorů a jejich prediktivní hodnota v náhodně vybraném populačním vzorku, Czech post-MONICA</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Hypertension

ISSN

1524-6175

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

897-905

Kód UT WoS článku

000534198500015

EID výsledku v databázi Scopus

2-s2.0-85083069299