Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10412844" target="_blank" >RIV/00216208:11140/20:10412844 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00669806:_____/20:10412844
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ryVY~BA9NK" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ryVY~BA9NK</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.14332" target="_blank" >10.21873/anticanres.14332</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination
Popis výsledku v původním jazyce
Aim: To compare iodine-related and fluorine-18 fluorodeoxyglucose (F-18-FDG) parameters during staging of lung cancer as well as during early follow-up, while investigating potential use and possible substitutability in the assessment of therapeutic response or prediction. Patients and Methods: Patients (n=45) with confirmed lung cancer underwent F-18-FDG positron-emission tomography (PET) using single-source dual-energy computed tomography was performed for staging and early follow-up. Correlation of FDG uptake and iodine-related parameters was assessed and comparison with therapy response was performed. Results: A strong correlation was found between the volumetric FDG parameters metabolic tumour volume (MTV) and total lesion glycolysis (TLG) and iodine uptake (IU) in staging (IU vs. MTV: r(s)=0.894; p<0.001 and IU vs. TLG: r(s)=0.874; p<0.001) and follow-up (IU vs. MTV: r(s)=0.934, p<0.001 and IU vs. TLG: r(s)=0.935, p<0.001). We also found significant correlation of change in these values between timepoints. We observed a significant correlation of IU, MTV and TLG with early therapy response and IU was found as a possible strong predictor. Conclusion: Strong correlation of IU and volume-based FDG parameters was proved in staging, follow-up and change during therapy. Potential role of IU in prediction of early therapy-response was identified. Our study suggests a significant benefit of using the dual-energy computed tomography as a part of F-18-FDG PET/CT in patients with lung cancer.
Název v anglickém jazyce
Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination
Popis výsledku anglicky
Aim: To compare iodine-related and fluorine-18 fluorodeoxyglucose (F-18-FDG) parameters during staging of lung cancer as well as during early follow-up, while investigating potential use and possible substitutability in the assessment of therapeutic response or prediction. Patients and Methods: Patients (n=45) with confirmed lung cancer underwent F-18-FDG positron-emission tomography (PET) using single-source dual-energy computed tomography was performed for staging and early follow-up. Correlation of FDG uptake and iodine-related parameters was assessed and comparison with therapy response was performed. Results: A strong correlation was found between the volumetric FDG parameters metabolic tumour volume (MTV) and total lesion glycolysis (TLG) and iodine uptake (IU) in staging (IU vs. MTV: r(s)=0.894; p<0.001 and IU vs. TLG: r(s)=0.874; p<0.001) and follow-up (IU vs. MTV: r(s)=0.934, p<0.001 and IU vs. TLG: r(s)=0.935, p<0.001). We also found significant correlation of change in these values between timepoints. We observed a significant correlation of IU, MTV and TLG with early therapy response and IU was found as a possible strong predictor. Conclusion: Strong correlation of IU and volume-based FDG parameters was proved in staging, follow-up and change during therapy. Potential role of IU in prediction of early therapy-response was identified. Our study suggests a significant benefit of using the dual-energy computed tomography as a part of F-18-FDG PET/CT in patients with lung cancer.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30224 - Radiology, nuclear medicine and medical imaging
Návaznosti výsledku
Projekt
<a href="/cs/project/NV17-30748A" target="_blank" >NV17-30748A: Nová metoda kombinace funkčních zobrazovacích metod a nádorové genomiky pro neinvazivní fenotypizaci a sledování efektu léčby plicních karcinomů</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Anticancer Research
ISSN
0250-7005
e-ISSN
—
Svazek periodika
40
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
GR - Řecká republika
Počet stran výsledku
10
Strana od-do
3459-3468
Kód UT WoS článku
000538104800051
EID výsledku v databázi Scopus
2-s2.0-85085908718