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Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10412844" target="_blank" >RIV/00216208:11140/20:10412844 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00669806:_____/20:10412844

  • Výsledek na webu

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ryVY~BA9NK" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ryVY~BA9NK</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21873/anticanres.14332" target="_blank" >10.21873/anticanres.14332</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination

  • Popis výsledku v původním jazyce

    Aim: To compare iodine-related and fluorine-18 fluorodeoxyglucose (F-18-FDG) parameters during staging of lung cancer as well as during early follow-up, while investigating potential use and possible substitutability in the assessment of therapeutic response or prediction. Patients and Methods: Patients (n=45) with confirmed lung cancer underwent F-18-FDG positron-emission tomography (PET) using single-source dual-energy computed tomography was performed for staging and early follow-up. Correlation of FDG uptake and iodine-related parameters was assessed and comparison with therapy response was performed. Results: A strong correlation was found between the volumetric FDG parameters metabolic tumour volume (MTV) and total lesion glycolysis (TLG) and iodine uptake (IU) in staging (IU vs. MTV: r(s)=0.894; p&lt;0.001 and IU vs. TLG: r(s)=0.874; p&lt;0.001) and follow-up (IU vs. MTV: r(s)=0.934, p&lt;0.001 and IU vs. TLG: r(s)=0.935, p&lt;0.001). We also found significant correlation of change in these values between timepoints. We observed a significant correlation of IU, MTV and TLG with early therapy response and IU was found as a possible strong predictor. Conclusion: Strong correlation of IU and volume-based FDG parameters was proved in staging, follow-up and change during therapy. Potential role of IU in prediction of early therapy-response was identified. Our study suggests a significant benefit of using the dual-energy computed tomography as a part of F-18-FDG PET/CT in patients with lung cancer.

  • Název v anglickém jazyce

    Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination

  • Popis výsledku anglicky

    Aim: To compare iodine-related and fluorine-18 fluorodeoxyglucose (F-18-FDG) parameters during staging of lung cancer as well as during early follow-up, while investigating potential use and possible substitutability in the assessment of therapeutic response or prediction. Patients and Methods: Patients (n=45) with confirmed lung cancer underwent F-18-FDG positron-emission tomography (PET) using single-source dual-energy computed tomography was performed for staging and early follow-up. Correlation of FDG uptake and iodine-related parameters was assessed and comparison with therapy response was performed. Results: A strong correlation was found between the volumetric FDG parameters metabolic tumour volume (MTV) and total lesion glycolysis (TLG) and iodine uptake (IU) in staging (IU vs. MTV: r(s)=0.894; p&lt;0.001 and IU vs. TLG: r(s)=0.874; p&lt;0.001) and follow-up (IU vs. MTV: r(s)=0.934, p&lt;0.001 and IU vs. TLG: r(s)=0.935, p&lt;0.001). We also found significant correlation of change in these values between timepoints. We observed a significant correlation of IU, MTV and TLG with early therapy response and IU was found as a possible strong predictor. Conclusion: Strong correlation of IU and volume-based FDG parameters was proved in staging, follow-up and change during therapy. Potential role of IU in prediction of early therapy-response was identified. Our study suggests a significant benefit of using the dual-energy computed tomography as a part of F-18-FDG PET/CT in patients with lung cancer.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30224 - Radiology, nuclear medicine and medical imaging

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NV17-30748A" target="_blank" >NV17-30748A: Nová metoda kombinace funkčních zobrazovacích metod a nádorové genomiky pro neinvazivní fenotypizaci a sledování efektu léčby plicních karcinomů</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Anticancer Research

  • ISSN

    0250-7005

  • e-ISSN

  • Svazek periodika

    40

  • Číslo periodika v rámci svazku

    6

  • Stát vydavatele periodika

    GR - Řecká republika

  • Počet stran výsledku

    10

  • Strana od-do

    3459-3468

  • Kód UT WoS článku

    000538104800051

  • EID výsledku v databázi Scopus

    2-s2.0-85085908718